West China Journal of Stomatology

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Influence of the Expression of Heat Shock Protein 70 in Maxillofacial Squamous Cell Carcinoma by Themochemotherapy

WANG Sheng-zhi1, WANGLi2, GAO Xiang-dong1,CHENG Zhou1, BIHong-guang1,WANG Da-zhang3   

  1. 1. Dept. ofOral andMaxillofacial Surgery,The Affiliated Yantai YuHuang DingHospital ofMedical College,Qingdao University, Yantai264000, China;2.Dept. ofStomatology,The Infirmary ofthe No.1Middle School of Yantai, Yantai264001, China;3.Dept. ofOral andMaxillofacial Surgery, West China College ofStomatology, Sichuan University, Chengdu610041, China
  • Received:2005-08-25 Revised:2005-08-25 Online:2005-08-20 Published:2005-08-20

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Abstract:

Objective　To study the influence of themochemotheraphy on the expression of HSP70 in maxillofacial squamous cell carcinoma.Methods　12 patients were treated with themochemotheraphy twice a week,altogether 10 times.After 8 mg of Pingyangmycin infused, the patients were treated with microwave hyperthermia at 43℃for 40 min.The part of carcinoma tissue was removed with surgical operations at before treatment and aftre five times of treatment. The expression ofHSP70 in tumor cells was determined by SP immunohitochemcial method.Results　The expression of HSP70 in tumor cells was enhanced obviously by thermochemotherapy.Conclusion　Special high expression of HSP70 in the tumor cells was induced by thermochemotherapy. With the antigen presenting action and other action,HSP70 have special antitumor effect.

Key words: thermochemotherapy, heat shock protein, tumor

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