West China Journal of Stomatology

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Study on the Relationship between Fas Expression and Apoptosis in Oral Squamous Cell Carcinoma

WANGJian-guang1, HUANGHong-zhang1,PANChao-bin1,HOUJin-song2,LIJin-song1,CHENG bin3   

  1. 1.Dept.ofOral andCranio-Maxillofacial Surgery,the SecondAffiliatedHospital; 2.Dept.ofOral andMaxillofacial Surgery,Guanghua College ofStomatology; 3.Dept. ofOral Medicine,Guanghua College ofStomatology,Sun Yat-sen University,Guangzhou510120,China
  • Received:2004-08-25 Revised:2004-08-25 Online:2004-08-20 Published:2004-08-20
  • Contact: 潘朝斌,Tel: 13902284035
  • Supported by:

    广东省自然科学基金资助项目(980121);中山大学科研基金资助项目(99-B002000007)

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Abstract:

Objective　To investigate the relationship of Fas mRNA and protein expression and apoptosis in human oral squa- mous cell carcinoma.Methods　Northern blot and flow cytometry (TUNELmethod) were used to detectthe expression of FasmR- NA and Fas protein, cell cycle and apoptotic level in oral squamous cell carcinoma. The relationship between Fas gene expression and OSCC apoptosis was analyzed statistically.Results　Fas mRNA and protein could be detected in all five normal oral mucosa specimens. There was positive correlation between expression of Fas mRNA/protein and cell differentiation as well as apoptosis in OSCC(P<0.005).Conclusion　The expression of Fas genewas highly correlatedwiththe differentiation and apoptosis in OSCC.

Key words: Fasgene, squamouscell, carcinoma, ;apoptosis

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