Clinical efficacy of demineralized dentin matrix particles in immediate implantation for bone defects in posterior region: a 1 to 5-year follow-up study

doi:10.7518/hxkq.2025.2024419

Abstract

Abstract:

Objective This study aims to evaluate the short- to medium-term clinical efficacy of demineralized dentin matrix (DDM) particles applied during the immediate implantation of alveolar bone defects in the posterior region. Methods A total of 76 patients with 110 simple taper retentive implants were included in the conducted study and divided into Groups A and B in accordance with the bone grafting materials. Cone beam computed tomography and panoramic radiographs were taken immediately after implant surgery, immediate crown repair, and final follow-up time. The average follow-up time for Groups A and B was recorded. The primary observed clinical indicators were overall survival rate of the implant, bone resorption of the mesial and distal margins of the implant, buccal bone width resorption at the platform level and 1 mm below the platform, and bone height of the implant. Implant complication was a secondary observed clinical indicator. Results During the 1-to-5-year follow-up observation period, the mean follow-up of Group A was 38.2 months while that of Group B was 39.9 months. In Group A, two implants failed, one of which fractured, and implant overall survival rate was 96.4%. Four implants failed in Group B due to peri-implantitis, and implant overall survival rate was 92.6%. No statistically significant difference in implant overall survival rate was found between the two groups (P>0.05). In Group A, the average bone resorption in the mesial and distal margins of the implants was (1.011±2.047) mm and (0.841±2.183) mm, respectively. In Group B, the average bone resorption of the mesial and distal margins of the implants was (1.546±1.778) mm and (1.431±1.909) mm, respectively. No statistically significant difference was noted between the two groups (P>0.05). In Group A, buccal bone width resorption at the platform level and 1 mm below the platform of the implant was (0.782±2.084) mm and (0.681±2.307) mm, respectively. In Group B, buccal bone width resorption at the platform level and 1 mm below the platform of implant was (1.071±1.474) mm and (0.949±1.909) mm, respectively. No statistically significant difference was found between the two groups (P>0.05). In Group A, the buccal bone height of resorption of the implant was (1.044±2.214) mm. In Group B, the buccal bone height of resorption of the implant was (1.075±1.456) mm. No statistically significant difference in bone height was observed between the two groups (P>0.05). Conclusion During the 1-to-5-year follow-up observation period, DDM particles can effectively increase the height and width of alveolar bone, and they can achieve the same effect of maintaining alveolar bone contour and bone augmentation compared with deproteinized inorganic calf bone. DDM particles can be used as a potential new bone grafting material for the treatment of bone defects in clinical practice.

Key words: demineralized dentin matrix particles, bone defect, immediate implantation, simple taper retention

CLC Number:

R783.4

Wu Hao, Cao Ning, Cao Liangwei, Yu Fei, Zhang Xu, Wei Shibo, Wei Hongwu, Guo Shuigen. Clinical efficacy of demineralized dentin matrix particles in immediate implantation for bone defects in posterior region: a 1 to 5-year follow-up study[J]. West China Journal of Stomatology, 2025, 43(4): 570-583.

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基本信息		A组	B组	P值
性别/n	男	24	25	0.811
	女	14	13
年龄/岁	≤65	26	22	0.515
	>65	13	15
上下颌/n	上颌	38	27	0.057
	下颌	18	27
种植位点/n	前磨牙	22	22	0.876
	磨牙	34	32
根尖是否有炎症	有	30	28	0.702
	无	25	27
是否有牙周炎	有	26	30	0.912
	无	9	11
平均随访时间/月	>38	18	20	0.646
	≤38	20	18

长度/mm	直径/mm					合计/n
长度/mm	3.5	4.0	4.5	5.0	6.0	合计/n
合计	7	15	34	44	6	106
5	0	0	3	3	2	8
6	0	1	13	31	4	49
7	0	0	4	0	0	4
8	6	9	13	8	0	36
10	0	3	1	2	0	6
11	1	2	0	0	0	3

组别	近中边缘骨高度/mm			近中边缘骨吸收量/mm
组别	T0	T1	T2	ΔT1-T0	ΔT2-T1	ΔT2-T0
P值	0.011	0.000	0.000	0.159	0.866	0.147
A组	4.510±1.836	3.981±1.592	3.499±1.454	-0.529±2.125	-0.481±0.543	-1.011±2.047
B组	3.688±1.442	2.642±1.195	2.142±1.400	-1.046±1.662	-0.500±0.605	-1.546±1.778

组别	远中边缘骨高度/mm			远中边缘骨吸收量/mm
组别	T0	T1	T2	ΔT1-T0	ΔT2-T1	ΔT2-T0
P值	0.125	0.000	0.000	0.204	0.416	0.135
A组	3.837±1.818	3.386±1.412	2.995±1.378	-0.450±2.211	-0.391±0.372	-0.841±2.183
B组	3.341±1.528	2.390±1.263	1.910±1.415	-0.950±1.873^a	-0.480±0.708^a	-1.431±1.909

组别	T0		T1		T2
组别	N0	B0	N1	B1	N2	B2
P值	0.036	0.116	0.003	0.017	0.002	0.012
A组	4.176±1.499	3.848±1.708	3.679±1.478	3.439±1.661	3.394±1.571	3.164±1.752
B组	3.659±1.012	3.414±1.083	2.948±1.034	2.802±1.018	2.588±1.060	2.465±1.020