Abstract:

 Objective  To evaluate the effects of non-surgical periodontal treatment on clinical periodontal measurements, glycemic control, and level of serum soluble intercellular adhesion molecule-1（sICAM-1） in type 2 diabetes mellitus with chronic periodontitis patients. Methods  Patients with type 2 diabetes and chronic periodontitis were selected and classified into well-controlled group[glycated hemoglobin A1c （ GHbA1c ） ＜7.00%, n=30, DMCP1 group] and poorly-controlled group（GHbA1c≥7.00%, n=30, DMCP2 group）. Thirty systemically healthy patients with chronic periodontitis were recruited as control group（CP group）. All subjects underwent non-surgical periodontal therapy. Plaque index（PLI）, sulcus bleeding index（SBI）, bleeding on probing（BOP）, probing depth（PD）, clinical attachment loss （CAL）, serum sICAM-1 concentration, and the value of fasting plasma glucose（FPG）, GHbA1c were recorded at baseline, 1 and 3 months after periodontal treatment. Results  The three study groups showed significant improvements for the levels of PD, SBI, PLI, BOP, and serum sICAM-1 concentration at 1 and 3 months after non-surgical periodontal treatment（P＜0.05）. The level of CP group and DMCP1 group also showed significant improvements for the levels of CAL（P＜0.05）, but no significant change was found in DMCP2 group（P＞0.05）. At 3 months after periodontal treatment, GHbA1c levels in DMCP2 group significantly decreased by 1.12%（P＜0.05）, whereas no significant changes were found in CP and DMCP1 groups（P＞0.05）. Conclusion  Non-surgical periodontal treatment can significantly improve periodontal health status in patients with type 2 diabetes and periodontitis, reduce the level of serum sICAM-1, and can reduce the level of GHbA1c in poorly controlled type 2 diabetic patients.

Key words:  chronic periodontitis, type 2 diabetes mellitus, non-surgical periodontal therapy, glycated hemoglobin A1c, soluble intercellular adhesion molecule-1