West China Journal of Stomatology ›› 2012, Vol. 30 ›› Issue (6): 628-631.doi: 10.3969/j.issn.1000-1182.2012.06.016

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Relationship between endothelial nitric oxide synthase Glu298Asp gene polymorphisms and the chronic periodontitis with type 2 diabetes mellitus

Hou Haijuan1, Zhang Fan2, Zhao Meilin1, Cao Guifen3, Huang Haiyun4, Huang Ping4.   

  1. 1. Dept. of Periodontology, The Affiliated Hospital of Stomatology, Chongqing Medical University; Chongqing Research Center for Oral Diseases and Biomedical Science, Chongqing 401147, China; 2. Dept. of Medical Examination Center, West China Hospital, Sichuan University, Chengdu 610041, China; 3. Dept. of Periodontology, The Affiliated Stomatological Hospital, College of Medicine, Zhejiang University, Hangzhou 310006, China; 4. Dept. of Periodontology, West China School of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2012-03-26 Revised:2012-09-23 Online:2012-12-01 Published:2012-12-01

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Abstract:

Objective To study the relationship between endothelial nitric oxide synthase（eNOS） Glu298Asp gene polymorphism and chronic periodontitis（CP） with type 2 diabetes mellitus（T2DM）. Methods DNA from patients’buccal swabs of CP, CP with T2DM, T2DM and health was isolated and extracted. The eNOS Glu298Asp gene polymorphism were assessed by polymerase chain reaction-restriction fragment length polymorphism（PCR-RFLP） respectively. Results The distribution of eNOS Glu298Asp genotype in CP group, T2DM group, CP with T2DM group and health group showed statistical differences（掊2＝18.503, P＝0.005）, and the gene frequency showed statistical differences（掊2= 8.243, P=0.041）. Compared health group to CP with T2DM group, OR value of the genetype T was 0.962, 95% confidence interval lay in between 0.737 to 1.256, which showed T maybe a protective factor. While OR value of the genetype G was 1.043, 95% confidence interval lay in between 0.781 to 1.391, which showed G maybe a risk factor. However, neither T nor G was statistically significant. Conclusion Based on these findings, there are some association between eNOS Glu298Asp polymorphism and the risk of CP group, T2DM group, CP with T2DM group.

Key words: chronic periodontitis, type 2 diabetes mellitus, nitric oxide synthase, gene polymorphism

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