West China Journal of Stomatology ›› 2020, Vol. 38 ›› Issue (4): 385-392.doi: 10.7518/hxkq.2020.04.006
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Chang Yaqin1(), Fang Fangfang1, Qin Shasha2, Dong Yingchun3, Chen Bin1(
)
Received:
2019-12-09
Revised:
2020-04-18
Online:
2020-08-01
Published:
2020-08-03
Contact:
Chen Bin
E-mail:361734128@qq.com
Supported by:
CLC Number:
Chang Yaqin, Fang Fangfang, Qin Shasha, Dong Yingchun, Chen Bin. Effect of scaling and root planing on serum C-reactive protein levels in patients with moderate to severe chronic periodontitis: a systematic review and Meta-analysis[J]. West China Journal of Stomatology, 2020, 38(4): 385-392.
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Tab 1
Characteristic of included studies
文献 | 年份 | 研究 | 人数 | 年龄/岁 | 性别(男/ | 吸烟 | 牙周炎程 | 干预措施 | 用药情况 | 随访 | 测量 | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
类型 | 女) | 度/类型 | 周期 | 方法 | |||||||||||||||
Ebersole等[ | 1997 | RCT | T:8 | 35~63 | NR | NR | 中重度 | T:SRP+口服 | T:服用某药; | 2 年 | ELISA | ||||||||
药物 | |||||||||||||||||||
C:26 | C:SRP | C:服用安慰剂 | |||||||||||||||||
Ide等[ | 2003 | RCT | T:24 | T:47.8±7.5 | T:13/11 | N | 中重度 | T:OHI+SRP | N | 3个月 | ELISA | ||||||||
C:15 | C:46.0±6.2 | C:10/5 | C:无 | ||||||||||||||||
D’Aiuto等[ | 2005 | RCT | T1:21 | T1:48±7 | T1:11/10 | Y | 重度广泛型 | T1:OHI+SRP | T2:局部用盐酸 | 2个月 | 免疫比浊法 | ||||||||
T2:20 | T2:49±7 | T2:12/8 | T2:OHI+SRP+ | 米诺环素 | |||||||||||||||
局部用药 | |||||||||||||||||||
C:24 | C:48±6 | C:15/9 | C:无 | ||||||||||||||||
D’Aiuto等[ | 2006 | RCT | T:20 | T:47±7 | T:10/10 | Y | 重度广泛型 | T:OHI+SRP+ | T:局部用米诺 | 6个月 | 免疫比浊法 | ||||||||
局部用药 | 环素 | ||||||||||||||||||
C:20 | C:48±7 | C:12/8 | C:OHI+SPR | ||||||||||||||||
Kamil等[ | 2011 | RCT | T:18 | T:46.7±3.4 | T:10/8 | N | 重度 | T:OHI+SRP | N | 3个月 | 免疫比浊法 | ||||||||
C:18 | C:45.4±3.3 | C:10/8 | C:OHI | ||||||||||||||||
Shetty等[ | 2013 | RCT | T:20 | 25~55 | NR | N | 中重度 | T:OHI+SRP+ | T:服用某药; | 6个月 | 免疫比浊法 | ||||||||
口服药物 | |||||||||||||||||||
C:20 | C:OHI+SRP | C:服用安慰剂 | |||||||||||||||||
Caúla等[ | 2014 | RCT | T:32 | T:44.4 | T:20/12 | Y | 重度 | T:OHI+SRP | N | 6个月 | 化学免疫测 | ||||||||
C:32 | C:44.01 | C:19/13 | C:无 | 定 | |||||||||||||||
文献 | 年份 | 研究 | 人数 | 年龄/岁 | 性别(男/ | 吸烟 | 牙周炎程 | 干预措施 | 用药情况 | 随访 | 测量 | ||||||||
类型 | 女) | 度/类型 | 周期 | 方法 | |||||||||||||||
Al Habash- | 2015 | RCT | T:20 | T:39.7±13.7 | T:6/14 | N | 重度 | T:SRP+臭氧 | T:局部用臭氧 | 3个月 | ELISA | ||||||||
neh等[ | 水冲洗 | 水冲洗 | |||||||||||||||||
C:21 | C:39.0±10.2 | C:7/14 | C:SRP+蒸馏 | ||||||||||||||||
水冲洗 | |||||||||||||||||||
Graziani等[ | 2015 | RCT | T:19 | T:48±9 | T:9/10 | Y | 中度以上 | T:OHI+Q-SRP | NR | 90 d | 免疫比浊法 | ||||||||
C:19 | C:46±12 | C:10/9 | C:OHI+FM- | ||||||||||||||||
SRP | |||||||||||||||||||
王崇丽等[ | 2015 | RCT | T:50 | NR | NR | NR | 中重度 | T:OHI+ SRP | NR | 3个月 | ELISA | ||||||||
C:50 | C:健康对照组 | ||||||||||||||||||
白驹[ | 2017 | RCT | T:42 | 40.72±4.19 | 45/40 | NR | 中重度 | T:SRP+盐酸 | T:局部用盐酸 | 6个月 | NR | ||||||||
米诺环素 | 米诺环素 | ||||||||||||||||||
C:43 | C:SRP | ||||||||||||||||||
Suryapra- | 2018 | RCT | T:15 | 30~50 | NR | N | 中重度 | T:SRP+克拉 | NR | 6个月 | ELISA | ||||||||
sanna等[ | 霉素 | ||||||||||||||||||
C:15 | C:SRP | ||||||||||||||||||
Graziani等[ | 2019 | RCT | T:19 | 50.89±10.08 | 8/11 | Y | 中重度 | T:SRP+局部 | NR | 3个月 | NR | ||||||||
用药 | |||||||||||||||||||
C:19 | C:SRP | ||||||||||||||||||
陈群等[ | 2009 | CCT | 20 | 57.0±12.3 | 14/6 | NR | 中重度 | OHI+ SRP | NR | 3个月 | NR | ||||||||
Acharya等[ | 2010 | CCT | 15 | 45.1±7.1 | NR | N | 中重度 | OHI+SRP | NR | 2个月 | ELISA | ||||||||
Graziani等[ | 2010 | CCT | 14 | 491(15)2 | 8/6 | Y | 广泛型重度 | OHI+SRP | NR | 6个月 | NR | ||||||||
Pej?i?等[ | 2011 | CCT | 20 | 43.4±7.8 | 0/20 | N | 广泛型中重度 | OHI+SRP | NR | 2个月 | ELISA | ||||||||
周于翔[ | 2011 | CCT | 6 | 40~77 | NR | NR | 广泛型中重度 | OHI+SRP | NR | 3个月 | 免疫比浊法 | ||||||||
兰倩等[ | 2013 | CCT | 27 | 43.12±6.01 | 17/10 | N | 广泛型中重度 | OHI+SRP | NR | 3个月 | NR | ||||||||
Torumtay等[ | 2016 | CCT | 25 | 48.32±7.39 | NR | N | 中重度 | OHI+SRP | NR | 6个月 | ELISA | ||||||||
Yang等[ | 2018 | CCT | 31 | (50±8)3 | 11/20 | NR | 中重度 | SRP | NR | 8 周 | ELISA | ||||||||
薛媛等[ | 2018 | CCT | 80 | 41.3±5.2 | 28/52 | N | 中重度 | OHI+SRP | NR | 6个月 | 免疫比浊法 | ||||||||
Marcaccini | 2009 | CCT | 25 | 44.90±5.5 | 9/16 | N | 重度 | OHI+SRP | NR | 3个月 | 免疫比浊法 | ||||||||
等[ | |||||||||||||||||||
罗志晓等[ | 2005 | CCT | 22 | 40-55 | 10/12 | N | 中重度 | OHI+SRP | NR | 2个月 | ELISA | ||||||||
全茂伟等[ | 2019 | CCT | 40 | 51.2±7.3 | 23/17 | NR | 中重度 | OHI+SRP | 不用抗生素 | 6个月 | 透射免疫比 | ||||||||
浊法 |
Tab 2
MINORS evaluation results of non-randomized controlled trials
文献 | 研究 | 纳入患 | 预期 | 终点指标 | 终点指 | 随访时 | 失访 | 是否估 | 对照组的 | 对照组 | 组间基 | 统计分 | 总分 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
目的 | 者连贯 | 数据 | 反映研究 | 标评价 | 间是否 | 率低 | 计了样 | 选择是否 | 是否同 | 线是否 | 析是否 | ||
明确 | 性 | 收集 | 目的 | 客观性 | 充分 | 于5% | 本量 | 恰当 | 步 | 可比 | 恰当 | ||
Acharya等[ | 2 | 0 | 2 | 2 | 0 | 0 | 2 | 0 | 2 | 1 | 1 | 2 | 14 |
Marcaccini等[ | 2 | 2 | 2 | 2 | 0 | 1 | 1 | 0 | 1 | 2 | 1 | 2 | 16 |
Pej?i?等[ | 2 | 1 | 2 | 2 | 1 | 0 | 2 | 0 | 2 | 2 | 2 | 2 | 18 |
Torumtay等[ | 2 | 1 | 2 | 2 | 0 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 21 |
陈群等[ | 2 | 1 | 2 | 2 | 0 | 1 | 2 | 0 | 2 | 2 | 1 | 2 | 17 |
罗志晓等[ | 2 | 0 | 2 | 2 | 0 | 0 | 2 | 0 | 1 | 0 | 0 | 2 | 11 |
薛媛等[ | 2 | 1 | 2 | 2 | 0 | 1 | 2 | 0 | 1 | 2 | 0 | 2 | 15 |
周于翔[ | 2 | 1 | 2 | 2 | 0 | 1 | 2 | 0 | 2 | 2 | 2 | 2 | 18 |
Graziani等[ | 2 | 1 | 2 | 2 | 0 | 2 | 2 | 2 | / | / | / | / | 13 |
兰倩等[ | 2 | 1 | 2 | 2 | 0 | 1 | 0 | 0 | / | / | / | / | 8 |
Yang等[ | 2 | 2 | 2 | 2 | 0 | 1 | 2 | 0 | / | / | / | / | 11 |
全茂伟等[ | 2 | 1 | 2 | 2 | 1 | 2 | 2 | 0 | / | / | / | / | 12 |
[1] | 闫福华. 牙周炎对全身疾病和健康影响的研究进展[J]. 口腔医学, 2018,38(7):577-581. |
Yan FH . Research progress of impacts of periodontitis on systemic diseases and health[J]. Stomatology, 2018,38(7):577-581. | |
[2] | 和璐. 牙周炎和代谢综合征[J]. 北京大学学报(医学版), 2011,43(1):13-17 |
He L . Periodontitis and metabolic syndrome[J]. J Peking Univ (Heal Sci), 2011,43(1):13-17. | |
[3] |
Glurich I, Grossi S, Albini B, et al. Systemic inflammation in cardiovascular and periodontal disease: comparative study[J]. Clin Diagn Lab Immunol, 2002,9(2):425-432.
doi: 10.1128/cdli.9.2.425-432.2002 URL pmid: 11874889 |
[4] |
Gomes-Filho IS, Freitas Coelho JM, da Cruz SS, et al. Chronic periodontitis and C-reactive protein levels[J]. J Periodontol, 2011,82(7):969-978.
doi: 10.1902/jop.2010.100511 URL pmid: 21189085 |
[5] |
Tüter G, Kurtis B, Serdar M. Evaluation of gingival crevicular fluid and serum levels of high-sensitivity C-reactive protein in chronic periodontitis patients with or without coronary artery disease[J]. J Periodontol, 2007,78(12):2319-2324.
doi: 10.1902/jop.2007.070150 URL pmid: 18052704 |
[6] |
Paraskevas S, Huizinga JD, Loos BG. A systematic review and Meta-analyses on C-reactive protein in relation to periodontitis[J]. J Clin Periodontol, 2008,35(4):277-290.
doi: 10.1111/j.1600-051X.2007.01173.x URL pmid: 18294231 |
[7] |
Ide M, McPartlin D, Coward PY, et al. Effect of treatment of chronic periodontitis on levels of serum markers of acute-phase inflammatory and vascular responses[J]. J Clin Periodontol, 2003,30(4):334-340.
doi: 10.1034/j.1600-051x.2003.00282.x URL pmid: 12694432 |
[8] |
D’Aiuto F, Nibali L, Parkar M, et al. Short-term effects of intensive periodontal therapy on serum inflammatory markers and cholesterol[J]. J Dent Res, 2005,84(3):269-273.
URL pmid: 15723869 |
[9] |
Ebersole JL, Machen RL, Steffen MJ, et al. Systemic acute-phase reactants, C-reactive protein and haptoglobin, in adult periodontitis[J]. Clin Exp Immunol, 1997,107(2):347-352.
doi: 10.1111/j.1365-2249.1997.270-ce1162.x URL pmid: 9030874 |
[10] |
D’Aiuto F, Parkar M, Nibali L, et al. Periodontal infections cause changes in traditional and novel cardiovascular risk factors: results from a randomized controlled clinical trial[J]. Am Heart J, 2006,151(5):977-984.
doi: 10.1016/j.ahj.2005.06.018 URL pmid: 16644317 |
[11] |
Kamil W, Al Habashneh R, Khader Y, et al. Effects of nonsurgical periodontal therapy on C-reactive protein and serum lipids in Jordanian adults with advanced periodontitis[J]. J Periodont Res, 2011,46(5):616-621.
doi: 10.1111/j.1600-0765.2011.01380.x URL pmid: 21631509 |
[12] |
Shetty S, Bose A, Sridharan S, et al. A clinico-biochemical evaluation of the role of a herbal (Ayurvedic) immunomodulator in chronic periodontal disease: a pilot study[J]. Oral Health Dent Manag, 2013,12(2):95-104.
URL pmid: 23756425 |
[13] |
Caúla AL, Lira-Junior R, Tinoco EM, et al. The effect of periodontal therapy on cardiovascular risk markers: a 6-month randomized clinical trial[J]. J Clin Periodontol, 2014,41(9):875-882.
doi: 10.1111/jcpe.12290 URL pmid: 25041550 |
[14] |
Al Habashneh R, Alsalman W, Khader Y. Ozone as an adjunct to conventional nonsurgical therapy in chronic periodontitis: a randomized controlled clinical trial[J]. J Periodont Res, 2015,50(1):37-43.
URL pmid: 24665871 |
[15] |
Graziani F, Cei S, Orlandi M, et al. Acute-phase response following full-mouth versus quadrant non-surgical periodontal treatment: a randomized clinical trial[J]. J Clin Periodontol, 2015,42(9):843-852.
doi: 10.1111/jcpe.12451 URL pmid: 26309133 |
[16] | 王崇丽, 张继东, 廉哲勋, 等. 牙周基础治疗对牙周炎病人血清炎性因子水平及颈动脉内膜中层厚度影响[J]. 青岛大学医学院学报, 2015,51(2):181-183. |
Wang CL, Zhang JD, Lian ZX , et al. Effect of periodontal non-surgical treatment on levels of serum inflammatory mediators and carotid intima-media thickness[J]. Acta Acad Med Qingdao Univ, 2015,51(2):181-183. | |
[17] | 白驹. 米诺环素辅助治疗慢性牙周炎的疗效[J]. 中国社区医师, 2017,33(17):18-19. |
Bai J . Efficacy of minocycline in the treatment of chronic periodontitis[J]. Chin Community Dr, 2017,33(17):18-19. | |
[18] |
Suryaprasanna J, Radhika PL, Karunakar P, et al. Evaluating the effectiveness of clarithromycin as an adjunct to scaling and root planing: a randomized clinical trial[J]. J Indian Soc Periodontol, 2018,22(6):529-534.
doi: 10.4103/jisp.jisp_254_18 URL pmid: 30631232 |
[19] |
Graziani F, Gennai S, Petrini M, et al. Enamel matrix derivative stabilizes blood clot and improves clinical healing in deep pockets after flapless periodontal therapy: a randomized clinical trial[J]. J Clin Periodontol, 2019,46(2):231-240.
URL pmid: 30663788 |
[20] | 陈群, 吴赟, 骆凯, 等. 冠心病伴慢性牙周炎患者的牙周基础治疗干预研究[J]. 广东牙病防治, 2009,17(11):519-522. |
Chen Q, Wu Y, Luo K , et al. Research about the effect of periodontal non-surgical treatment on periodontitis patients accompanied with coronary heart disease[J]. J Dent Prev Treat, 2009,17(11):519-522. | |
[21] |
Acharya A, Bhavsar N, Jadav B, et al. Cardioprotective effect of periodontal therapy in metabolic syndrome: a pilot study in Indian subjects[J]. Metab Syndr Relat Disord, 2010,8(4):335-341.
doi: 10.1089/met.2010.0002 URL pmid: 20575683 |
[22] |
Graziani F, Cei S, Tonetti M, et al. Systemic inflammation following non-surgical and surgical periodontal therapy[J]. J Clin Periodontol, 2010,37(9):848-854.
doi: 10.1111/j.1600-051X.2010.01585.x URL pmid: 20546085 |
[23] | Pejčić A, Kesić L, Milašin J, et al. The effects of periodontal therapy on C-reactive protein and periodontal pathogens in periodontitis patients[J]. Acta Stomatol Croat, 2011,45(1):14-23. |
[24] | 周于翔. 牙周基础治疗对血清超敏C反应蛋白影响研究[J]. 中国实用口腔科杂志, 2011,4(8):478-480. |
Zhou YX . Effect of periodontal initial therapy on the serum C-reactive protein level[J]. Chin J Pract Stomatol, 2011,4(8):478-480. | |
[25] | 兰倩, 韩璐. 非手术治疗对重度慢性牙周炎患者血液C反应蛋白的影响[J]. 国际医药卫生导报, 2013,19(14):2130-2132. |
Lan Q, Han L . Effect of non-surgical periodontal therapy on C-reactive protein in advanced chronic periodontitis[J]. Int Med Health Guid News, 2013,19(14):2130-2132. | |
[26] |
Torumtay G, Kırzıoğlu FY, Öztürk Tonguç M, et al. Effects of periodontal treatment on inflammation and oxidative stress markers in patients with metabolic syndrome[J]. J Periodont Res, 2016,51(4):489-498.
doi: 10.1111/jre.12328 URL pmid: 26547140 |
[27] |
Yang NY, Wang CY, Chyuan IT, et al. Significant association of rheumatoid arthritis-related inflammatory markers with non-surgical periodontal therapy[J]. J Formos Med Assoc, 2018,117(11):1003-1010.
doi: 10.1016/j.jfma.2017.11.006 URL pmid: 29174174 |
[28] | 薛媛, 赵文峰, 刘继延. 慢性牙周炎牙周基础治疗前后血清超敏C反应蛋白与单核细胞趋化蛋白-1变化研究[J]. 中国实用口腔科杂志, 2018,11(2):84-87. |
Xue Y, Zhao WF, Liu JY . Influence of chronic periodontitis and periodontal therapy on sencm high-sensitivity C-reactive protein and monocyte chemoattractant protein-1[J]. Chin J Pract Stomatol, 2018,11(2):84-87. | |
[29] |
Marcaccini AM, Meschiari CA, Sorgi CA, et al. Circulating interleukin-6 and high-sensitivity C-reactive protein decrease after periodontal therapy in otherwise healthy subjects[J]. J Periodontol, 2009,80(4):594-602.
doi: 10.1902/jop.2009.080561 URL pmid: 19335079 |
[30] | 罗志晓, 周作华, 解晓琴, 等. 慢性牙周炎患者治疗前后血清CRP、sICAM-1水平的变化[J]. 口腔医学研究, 2005,21(5):537-539. |
Luo ZX, Zhou ZH, Xie XQ , et al. Effects of nonsurgical periodontal therapy on CRP and sICAM-1 levels of blood serum with chronic periodontitis patients[J]. J Compr Stomatol, 2005,21(5):537-539. | |
[31] | 全茂伟, 杨香菊, 魏燕, 等. 牙周基础治疗对中、重度牙周炎患者血脂和血清炎性因子超敏C反应蛋白的影响[J]. 实用口腔医学杂志, 2019,35(2):253-256. |
Quan MW, Yang XJ, Wei Y , et al. The effects of periodontal initial therapy on the levels of blood lipids and serum inflammatroy factor hs-CRP in patients with moderate or severe periodontitis[J]. J Pract Stomatol, 2019,35(2):253-256. | |
[32] |
Yousuf O, Mohanty BD, Martin SS, et al. High-sensitivity C-reactive protein and cardiovascular disease: a resolute belief or an elusive link[J]. J Am Coll Cardiol, 2013,62(5):397-408.
doi: 10.1016/j.jacc.2013.05.016 URL pmid: 23727085 |
[33] |
Köhler-Forsberg O, Buttenschøn HN, Tansey KE, et al. Association between C-reactive protein (CRP) with depression symptom severity and specific depressive symptoms in major depression[J]. Brain Behav Immun, 2017,62:344-350.
doi: 10.1016/j.bbi.2017.02.020 URL pmid: 28257825 |
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