West China Journal of Stomatology

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Biocompatibility of porous calcium phosphate ceramic nanocomposite

Zhang Kefu1, Zhang Shu1, Luo Zhiqiang1, Wang Jing1,2, Wang Tao3, Ou Guomin1,4, Wang Hu1,5   

  1. 1. State Key Laboratory of Oral Diseases, Sichuan University, Chengdu 610041, China; 2. Dept. of Orthodontics, West China School of Stomatology, Sichuan University, Chengdu 610041, China; 3. Dept. of Stomatology, Hainan Province People’s Hospital, Haikou 570311, China; 4. Dept. of Implantology, West China School of Stomatology, Sichuan University, Chengdu 610041, China; 5. Dept. of Radiology, West China School of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2012-04-25 Revised:2012-04-25 Online:2012-04-01 Published:2012-04-01
  • Contact: Wang Hu,Tel:028-85503662
  • About author:Zhang Kefu(1989—),男,北京人,学士


Objective To study the biocompatibility of porous calcium phosphate ceramics nanocomposite. Methods The biocompatibility was evaluated via experiments including the hemolysis test, hemopexis test, acute systemic toxicity test, pyrogen test, and intramuscular implant test, in which biphasic calcium phosphate nanocomposite(NanoBCP) presented as leaching solution, suspension or blocks of 5 mm×5 mm×1 mm. Animals including New Zealand Rabbits, Kunming mice, SD rats were selected as the host. Results The hemolysis of NanoBCP was 1.1%(<5%). Four coagulation index levels were within the normal range. In pyrogen test, the temperature of each experimental rat increased by 0.35, 0.40, 0.28 ℃(<0.60 ℃, in accordance with the pyrogen-free criterion for biomedical materials). No consequent death, dyspnoea, organ dysfunction, severe peritoneal irritation or ptosis was observed in acute systemic toxic test. Newly-formed fibrous tissue could be found after the implantation. Conclusion The material possesses outstanding biocompatibility and degradability with no toxicity or irritation, contains no pyrogen, as well as better degradation properties than biphasic calcium phosphate.

Key words: nanocomposite, scaffolds, calcium phosphate ceramics, biocompatibility