Selective laser sintering and performances of porous titanium implants

doi:10.7518/hxkq.2018.05.013

Abstract

Abstract:

Objective This work aims to analyze the mechanical properties and biocompatibility of porous titanium (Ti) implants fabricated by selective laser sintering (SLS) and investigate the promotion of osseointegration by porous titanium implant combined with chitosan (CS)/hydroxyapatite(HA) composite coating. Methods Ti6Al4V specimens were prepared, and CS/HA composite coating was fabricated on the surface of a portion of the specimens. The mechanical properties of the samples were observed by scanning electron microscope. MC3T3-E1 cells were cultured in vitro, and their biological properties in vitro were analyzed using live and dead viability cell staining method, methyl thiazolyl tetrazolium (MTT) staining, and alkaline phosphatase (ALP) level detection. The thread implant specimens were implanted in the femoral condyle of rabbits, and biological performance was evaluated in vivo. Results Quasi-elastic gradient of porous specimens decreased with in-creasing porosity, and the quasi-elastic gradient were close to cortical and cancellous bone when the porosities were 30% and 70%. The specimens showed good biocompatibility. Combined with CS/HA coating, the implants promoted the proliferation and differentiation of MC3T3-E1 cells and facilitated the entry of bone tissue into pores and good osteogenesis. Conclusion The porous titanium implant exhibited favorable mechanical properties and biocompatibility. Combined with CS/HA coating, the implant exhibited bone inducibility, which leads to stable osteogenesis.

Key words: selective laser sintering, titanium implant, chitosan/hydroxyapatite composite coating, biocompatibility

CLC Number:

R783.2

Ting Wei,Xinwei Zhang,Huiqiang Sun,Mengyun Mao. Selective laser sintering and performances of porous titanium implants[J]. West China Journal of Stomatology, 2018, 36(5): 532-538.

Figures/Tables 8

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