Abstract:

Objective After sinboneHT bone replacement（SBR） was implanted in animals, to evaluate the biocompatibility of SBR and compounded in autogenetic bone in the proportion of one to one in order to prepare for the clinical applications in the future. Methods Bone defects of 10 mm×10 mm×2 mm was made at the mandibular of rabbits, then SBR with different granule diameter and autogenetic bone was compounded in the proportion of being applied in the left defects, while autogenetic bone was implanted in the right defects and nothing was used in the right reformed defects. Animals were sacrificed at 2, 4 and 8 weeks respectively. The biologic capacity was evaluated with anatomy, X-rays studies and histology. Results SBR has better biocompatibility, which can effectively accelerate the reconstruction of bone defects and help the new bone by being compounded with autogenetic bone. It provides the appropriate scaffold or template which would allow cellular infiltration, attachment and multiplication. Conclusion SBR is a kind of bone substitute material with good biocompatibility. SBR compounded with self-bone has a better regeneration function.

Key words: critical size defect, sinboneHT bone replacement, biocompatibility, autogenetic bone