华西口腔医学杂志 ›› 2026, Vol. 44 ›› Issue (2): 232-239.doi: 10.7518/hxkq.2026.2025350

• 基础研究 • 上一篇    

基于气相色谱-质谱技术对复合树脂牙科材料的安全性研究

李钰洁1(), 曾沂涌1, 杜振霞1(), 任桂芳2()   

  1. 1.北京化工大学化学学院,北京 100029
    2.北京市和平里医院口腔科,北京 100013
  • 收稿日期:2025-08-27 出版日期:2026-04-01 发布日期:2026-03-31
  • 通讯作者: 杜振霞,任桂芳 E-mail:17631835101@163.com;duzx@mail.buct.edu.cn;3786611411@qq.com
  • 作者简介:李钰洁,硕士,E-mail:17631835101@163.com

Safety study of resin-based dental materials using gas chromatography-mass spectrometry techniques

Li Yujie1(), Zeng Yiyong1, Du Zhenxia1(), Ren Guifang2()   

  1. 1.College of Chemistry, Beijing University of Chemical Technology, Beijing 100029, China
    2.Dept. of Stomatology, Beijing HePingLi Hospital, Beijing 100013, China
  • Received:2025-08-27 Online:2026-04-01 Published:2026-03-31
  • Contact: Du Zhenxia,Ren Guifang E-mail:17631835101@163.com;duzx@mail.buct.edu.cn;3786611411@qq.com

摘要:

目的 探究牙用粘接剂及复合树脂牙科材料的临床使用安全性。 方法 基于气相色谱-质谱(GC-MS)技术,对临床上应用的牙本质粘接剂及复合树脂材料,在pH分别为5.5、6.2、7.4、8.0的唾液模拟液、50%乙醇溶液和超纯水中的迁移物开展非靶向筛查。通过模拟口腔不同环境下的迁移情况,迁移液中共检出6种迁移物。利用GC-MS/氢火焰离子化检测器(FID)对迁移物进行定量分析,结合迁移物的毒性数据进行风险评估。 结果 在6种迁移液中,4个品牌的材料迁移出的单体和光引发剂的暴露量均在安全阈值内。 结论 本研究通过对牙科修复材料中迁移物进行了非靶向检测,并对其安全性进行了评估,迁移出的物质的暴露量均在安全阈值内,为临床修复使用安全的复合树脂牙科材料提供了依据。

关键词: 复合树脂牙科材料, 气相色谱-质谱, 迁移物, 风险评估

Abstract:

Objective To investigate the clinical application safety of dental adhesives and composite resin-based dental materials. Methods A non-targeted screening of migrants from clinically used dentin adhesives and composite resin materials was conducted using gas chromatography-mass spectrometry (GC-MS). Migration media included saliva simulants with pH of 5.5, 6.2, 7.4, and 8.0, 50% ethanol solution, and ultrapure water. By simulating migration under va-rious oral environments, six migrants were detected in the migration media. GC-MS/flame ionization detector was used for quantitative analysis of these migrants, and risk assessment was performed by combining their toxicity data. Results In all six migration media, the exposure levels of monomers and photoinitiators released from four commercially avai-lable resin-based dental materials were all within established safety thresholds. Conclusion This study conducted nontargeted detection and safety assessment of migrants from dental restorative materials. The exposure levels of all detected compounds were below safety limits, providing scientific evidence supporting the clinical safety of composite resin-based dental materials.

Key words: resin-based dental materials, gas chromatography-mass spectrometry, migrations, risk assessment

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