关键词: 人类主要组织相容抗原Ⅰ类分子, 口腔白斑, 口腔鳞状细胞癌, 免疫组织化学, 异常增生

Abstract:

Objective The purpose of this study was to examine the expression of human major histocompatibilitycomplex-Ⅰ at different degrees of dysplasia leukoplakia, and to investigate local immune status and discuss their associations with oral leukoplakia. Methods The monoclonal antibody of MHC classⅠantigen was employed in this study. There were 55 oral leukoplakias, 31 primary oral squamous cell carcinomas and 28 histologically normal oral epithelia were detected for the presence of the MHC class Ⅰ molecule by using immunohistochemistry method. Results The MHC class Ⅰ antigen expression of the severe dysplasia and oral squamous cell carcinoma was significantly lower than that of the normal epithelia（P<0.05）. But their expression did not show statistically difference between the normal epithelia and other groups of oral leukoplakia（P＞0.05）. Conclusion The expression levels of the MHC class Ⅰantigen is reduced in oral leukoplakia, particularly in severe dysplasia oral leukoplakia, it is relevant to the degree of dysplasia.

Key words: human major histocompatibility complex - Ⅰ , oral leukoplakia, oral squamous cell carcinoma, immunohistochemistry, dysplasia