华西口腔医学杂志

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纳米复合材料nHA-PA66对感染根管细菌的体外抑菌作用

叶 玲1,苏 勤1,周学东1,肖晓蓉2   

  1. 1.四川大学华西口腔医院 牙体牙髓病科;2.口腔生物医学工程教育部重点实验室,四川大学,四川 成都610041
  • 收稿日期:2005-12-25 修回日期:2005-12-25 出版日期:2005-12-20 发布日期:2005-12-20
  • 通讯作者: 苏 勤,Tel:028-85501439
  • 作者简介:叶 玲(1975-),女,重庆人,讲师,博士
  • 基金资助:
    四川省科委科技攻关资助项目(02SG022-001)

Antibacterial Effect of nHA-PA66in vitro

YELing1,SUQin1,ZHOUXue-dong1,XIAOXiao-rong2   

  1. 1.Dept.ofCon- servative Dentistry,West China College ofStomatology,Sichuan University,Chengdu610041,China;2.Key.Laboratory ofOral Biomedical EngineeringMinistry ofEducation,Sichuan University,Chengdu610041,China
  • Received:2005-12-25 Revised:2005-12-25 Online:2005-12-20 Published:2005-12-20

摘要: 目的 研究纳米复合材料nHA-PA66对感染根管优势菌的体外抑菌效果。方法 采用琼脂扩散法研究 nHA-PA66对牙龈卟啉单胞菌、具核梭杆菌和中间普氏菌的抑菌效果,以所形成的抑菌环直径为评价指标。结果  nHA-PA66粉剂对牙龈卟啉单胞菌和中间普氏菌有较好的抑菌效果,聚合后膜片抑菌效果较粉剂差,两者对具核梭 杆菌无抑菌作用。结论 nHA-PA66对感染根管细菌的抑菌效果不够理想,用作根充材料还需辅以抗菌性能好的 其他物质。

关键词: 抗菌性, nHA-PA66, 优势菌, 感染根管

Abstract: Objective To evaluate the antibacterial activity of nHA-PA66 on the predominant bacteria of infected root canalin vitro.Methods Agar diffusion method was the testing method.Porphyromonas gingivalis(P.gingivalis),Fusobacteria nuclea- tum(F.nucleatum) andPrevotalla intermedius(P.intermedius) were the tested bacteria. The powder and polymerized film of nHA-PA66 were the testmateialswhile the CCQ and filter paper as the control.Results nHA-PA66′s powder showed good ante- bacterial effect on theP.gingivalisandP.intermedius, its filmwasweaker. Both of them had no effect onF.nucleatum.Con- clusion nHA-PA66′s antibacterial effect was not ideal, for better clinical results, some additives can be included.

Key words: antibacterial activity, nHA-PA66, predominant bacterial, infected root canal