关键词: 盐酸米诺环素, 甲硝唑, 牙周炎, 龈下微生物

Abstract:

Objective　To compare the efficacy of 2 available periodontal systems for local delivery of antibiotics.Methods　26 teeth with moderate to severe periodontitis (PD≥4 mm) from 11 patientswere selected. The teethwere randomly divided into test group and control group. Periocline (2% minocycline hydrochoride ointment) was applied tothe teeth in the test group, while Ya- kang (local metronidazole) was applied in the control group. The data including clinical indices and microbiological parameters was collected before and on the 7th, 14thday after the therapy.Results　Before treatment, the mean of each clinical indices and microbiological parameters between the two groups was not different (P>0.05). But both groups demonstrated significant differ- ences with control after treatment (P<0.05), while there were no significant differences between the two test groups (P>0. 05).Conclusion　Both Periocline and Yakang were effective and secure local delivery drug for treating periodontitis.

Key words: minocycline hydrochoride, metronidazole, periodontitis, subgingival microbe