氯奎减缓过氧化氢自分解作用的检测

华西口腔医学杂志

氯奎减缓过氧化氢自分解作用的检测

管泽民,吴东红,黄国强,刘兴国,鱼洁

450003　河南省人民医院口腔科

收稿日期:2003-02-25 修回日期:2003-02-25 出版日期:2003-02-20 发布日期:2003-02-20

Inhibitive Effects of Chloroqquine on the Decomposition of Hydrogen Peroxide

GUANZemin,WUDonghong,HUANG Guoqiang,et al.

Department ofStomatology,Henan Provincial People′s Hospital,Zheng- zhou450003,China

Received:2003-02-25 Revised:2003-02-25 Online:2003-02-20 Published:2003-02-20

摘要/Abstract

摘要：

目的　检测和验证氯奎(CQ)对过氧化氢( HP)自分解作用的抑制效果。方法　依据辣根过氧化物酶与底物(OPD-HP)反应发生颜色改变原理,将以HP为主要成分的色素牙漂白剂分成4组,分别加入不同剂量的CQ,应用灵敏的酶联免疫实验方法,对HP的稳定性进行了3个月的追踪检测。结果　4组制剂随贮存时间的延长,其吸光值都降低,但程度不同,和CQ的含量呈依赖关系。CQ含量越高其吸光值越大,最高浓度与对照组比较,高4~6倍。结论　CQ具有抑制HP自分解的作用。用含HP的漂白剂治疗色素牙时,加入适量CQ,不但漂白效果好,而且有效期延长。

关键词: 过氧化氢, 稳定性, 牙漂白

Abstract:

Objective　The purposes of this study were to investigate effects of chloroqquine (CQ) on inhibiting the decom- position of hydrogen peroxides (HP), and to optimize composition of the tooth- bleaching agent.Methods　According to the princi- ple of the color-changing reaction between horse radish peroxidase and substrate, the tooth-bleaching agent made of HP was divided into fourgroupswith different amounts of CQ. The stability ofHPwas observed using ELISAfor3 months.Results　Withthe prolon- gation of store time, the absorbance of HP solutions containing different concentrations of CQ declined at different degrees, which showed a dependent relation between absorbance values and concentrations of CQ. Within the range of experiment concentrations of CQ, the higher the concentration of CQwas, the strongerthe stability ofHPwas. And the duration of tooth-bleaching effects in 150. 0 mg/ml of CQwas prolonged 4 to 6 times compared to thatwithout CQ.Conclusion　The data indicate that CQ can inhibit the de- composition of HP. The bleaching effect of the tooth-bleaching agent which is made of HP and proper amount of CQ is satisfactory.

Key words: hydrogen peroxides, stability, tooth bleaching

管泽民,吴东红,黄国强,刘兴国,鱼洁. 氯奎减缓过氧化氢自分解作用的检测[J]. 华西口腔医学杂志.

GUANZemin,WUDonghong,HUANG Guoqiang,et al.. Inhibitive Effects of Chloroqquine on the Decomposition of Hydrogen Peroxide[J]. West China Journal of Stomatology.

[1]	罗文佶, 黄文凯, 徐明华, 任玲, 程玉瑶, 战德松, 付佳乐. 10种复合树脂颜色稳定性与吸水溶解性研究[J]. 华西口腔医学杂志, 2023, 41(1): 58-66.
[2]	张润荃,李大军,赵晓一. 渗透树脂与前牙美学树脂颜色稳定性的比较研究[J]. 华西口腔医学杂志, 2019, 37(3): 270-274.
[3]	章可可, 周学东, 徐欣. 口腔中过氧化氢的来源及在微生态平衡中的作用[J]. 华西口腔医学杂志, 2017, 35(2): 215-220.
[4]	张希茜刘建彰谭建国杨洋徐军. 语音法确定健康成年人水平颌位关系稳定性的研究[J]. 华西口腔医学杂志, 2015, 33(5): 488-491.
[5]	李雪燕邓梦旋袁小平. 正畸正颌联合矫治骨性Ⅲ类错牙合畸形前牙位置及硬组织稳定性的系统评价[J]. 华西口腔医学杂志, 2015, 33(3): 267-271.
[6]	王立凯刘亚男郑焱李萍萍. 人工老化对不同厚度瓷聚体及不同类型树脂黏固材料颜色稳定性的影响[J]. 华西口腔医学杂志, 2015, 33(2): 201-205.
[7]	董晶张哲湛周国良. Ⅱ类骨质中正畸微种植体锥度及植入角度对支抗稳定性影响的三维有限元分析[J]. 华西口腔医学杂志, 2014, 32(1): 13-17.
[8]	唐健霞冯云枝. 漂白剂对玻璃离子水门汀类材料充填Ⅴ类洞边缘微渗漏的影响[J]. 华西口腔医学杂志, 2012, 30(4): 414-416.
[9]	曾金玲许天民林久祥. Begg及Edgewise矫治器减数治疗安氏Ⅱ类1分类错的硬组织变化及其稳定性[J]. 华西口腔医学杂志, 2008, 26(03): 275-278.
[10]	刘妍,许天民,林久祥. 安氏Ⅱ类1分类拔牙病例正畸治疗后后牙关系的稳定性研究[J]. 华西口腔医学杂志, 2004, 22(04): 298-301.
[11]	韩栋伟,李巧明,周平,杨涛,刘莉,李秉鸿. 功能性肌压等压区排牙法修复全口义齿的疗效评价[J]. 华西口腔医学杂志, 2003, 21(03): 220-221.
[12]	庞若愚　张蓉　章锦才　张蕴惠　俞少杰. 口腔链球菌丙酮酸氧化酶基因缺陷型变异株的构建[J]. 华西口腔医学杂志, 2002, 20(01): 62-65.
[13]	梁星,赵志河,唐思青,白丁,吕丹,巢永烈,丁运萍. 羟基磷灰石涂层钛种植支抗的稳定性[J]. , 1998, 16(02): 0-.
[14]	孟玉坤,巢永烈,廖运茂,杜传诗,王航. 粉浆涂塑渗透陶瓷烧结线性收缩率的测定[J]. , 1998, 16(02): 0-.
[15]	吴效民，徐恒昌，宋世卿. 金瓷修复体着色技术对着色剂色稳定性的影响[J]. , 1996, 14(04): 0-.