口腔粘膜癌前病变患者细胞DNA修复功能的检测

华西口腔医学杂志

口腔粘膜癌前病变患者细胞DNA修复功能的检测

林梅,岳玉敏,李秉琦,周敏,夏娟,张纲

610041 四川大学华西口腔医学院(林梅,李秉琦,周敏,夏娟,张纲,何园),华西医科大学牙种植医院 (岳玉敏)

收稿日期:2001-08-25 修回日期:2001-08-25 出版日期:2001-08-20 发布日期:2001-08-20
基金资助:
本课题为四川省卫生厅科研经费资助项目(编号F:0068)

The Examination of DNA Repair Capacity in the Patients with Oral Precancerous Lesion

LinMei, Li Bingqi, Zhou Min, et al

LinMei, Li Bingqi, Zhou Min, et al The College ofStomatology,West China UniversityofMedicalSciences Yue Yumin Hospital of Dental Implantation, West China University of MedicalSciences

Received:2001-08-25 Revised:2001-08-25 Online:2001-08-20 Published:2001-08-20

摘要/Abstract

摘要：

目的:探讨口腔粘膜癌前病变患者DNA修复水平的变化。方法:采用宿主细胞再活化反应性检测癌前病变组和正常对照组的16对配对病例,同时对吸烟、饮酒、家族史三项重要危险因素进行调查分析。结果:癌前病变患者细胞再活化反应性显著低于正常对照组(P<0105),该项指标在癌前病变发生中属重要危险因素,OR为3125 (95%CI=1101~10149)。结论:宿主细胞再活化反应性可用于临床辅助判断癌前病变预后和针对性监控的指标。

关键词: 口腔粘膜癌前病变, DNA修复功能, 遗传易感性, 宿主细胞再活化反应性

Abstract:

Objective:The occurrence of oral precancerous lesion is related with not only carcinogenic environmental factors but also some self-regulating mechanisms. The genetic heredity factors determine individualcs DNA repair capacity. The study is attempted to investigate the change of DNA repair capacity of the patientswith the precancerous lesion.Methods:The study is conducted in 16 pairs of oral precancerous lesion and normal controls by using host cell reactivation assay, while some dangerous factors such as smoking, alcohol intaking and family history of cancers are also recorded.Results:The host cell reactivation in the patients with precancerous lesion is lower than that of normal controls (P<0.05) and is shown to be an independent risk factor in the occur- rence of oral precancerous lesion (OR: 3.25 95%CI=1.01~10.49 ).Conclusion:The host cell reactivation is likely to be a helpful indicator for predict prognosis of cancer for the individuals with highly genetic sensitivity to cancer.

Key words: oral precancerous lesion, DNA repair capacity, genetic susceptibility, host cell reactivation

林梅,岳玉敏,李秉琦,周敏,夏娟,张纲. 口腔粘膜癌前病变患者细胞DNA修复功能的检测[J]. 华西口腔医学杂志.

LinMei, Li Bingqi, Zhou Min, et al. The Examination of DNA Repair Capacity in the Patients with Oral Precancerous Lesion[J]. West China Journal of Stomatology.