牙周炎对肥胖小鼠内脏重量和系数的影响

doi:10.7518/hxkq.2018.05.010

华西口腔医学杂志 ›› 2018, Vol. 36 ›› Issue (5): 514-520.doi: 10.7518/hxkq.2018.05.010

牙周炎对肥胖小鼠内脏重量和系数的影响

余挺¹(),赵莉²,章锦才³,轩东英⁴()

^1. 广州医科大学附属口腔医院牙周科·广州口腔疾病研究所·口腔医学重点实验室,广州 510140;
^2. 中山大学光华口腔医学院·附属口腔医院口腔修复科,广东省口腔医学重点实验室,广州 510055;
^3. 中国科学院大学存济医学院,北京 100049
^4. 中国科学院大学存济医学院,杭州口腔医院牙周科,杭州 310006

收稿日期:2018-02-11 修回日期:2018-07-09 出版日期:2018-10-01 发布日期:2018-10-18
作者简介:余挺,主治医师,博士,E-mail： dent_yu@163.com
基金资助:
国家自然科学基金(81700985);国家自然科学基金(81371151);国家自然科学基金(81470750);广州市卫生和计划生育科技项目(20181A011102)

Impacts of periodontitis on visceral organ weight and weight percentage in obese mice

Ting Yu¹(),Li Zhao²,Jincai Zhang³,Dongying Xuan⁴()

^1. Dept. of Periodontology, Stomatology Hospital of Guangzhou Medical University, Key Laboratory of Oral Medicine, Guangzhou Institute of Oral Disease, Guangzhou 510140, China
^2. Dept. of Prosthodontics, Guanghua School of Stomatology, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510055, China
^3. Savaid Medical School, University of Chinese Academy of Sciences, Beijing100049, China
^4. Dept. of Periodon-tology, Hangzhou Dental Hospital, Savaid Medical School, University of Chinese Academy of Sciences, Hangzhou 310006, China

Received:2018-02-11 Revised:2018-07-09 Online:2018-10-01 Published:2018-10-18
Supported by:
The National Natural Science Foundation of China(81700985);The National Natural Science Foundation of China(81371151);The National Natural Science Foundation of China(81470750);Guangzhou Health and Family Planning Technology Project(20181A011102)

摘要/Abstract

摘要：

目的探索肥胖状态下牙周炎对模型动物的内脏重量和系数的影响。方法将64只C57BL/6J小鼠随机分为高脂饲料（HFD）组（n=36）和低脂饲料（LFD）（n=28）组,HFD组诱导肥胖至处死,LFD组作为正常体重对照。诱导16周,两饲料组均再分为牙周炎（P）组和对照（C）组,P组用长有牙龈卟啉单胞菌的丝线分别结扎5、10 d诱导牙周炎,C组做假性结扎。结扎后处死小鼠,分离内脏称重并计算内脏系数。结果与LFD组相比,HFD组上调内脏脂肪和脾的重量、系数（P<0.05）,上调肝、肾重量（P<0.05）,下调肝系数和肾系数（P<0.01）。HFD组中,P组相对于C组下调脾重量和系数（P<0.05）,而结扎10 d相对于结扎5 d上调脾重量和系数（P<0.05）。结论牙周炎可影响肥胖模型动物内脏（特别是脾脏）的大体形态,该现象在肥胖与牙周炎的相互关系中可能具有免疫代谢学层面的病理意义。

关键词: 肥胖, 牙周炎, 内脏, 脾, 病理

Abstract:

Objective This study aimed to explore the impacts of periodontitis on the visceral weight and weight percen-tage of obese animal models. Methods A total of 64 C57BL/6J mice were divided into the following diet groups: high-fat diet (HFD) group (n=36), which was fed with high-fat diet to induce obesity, and low-fat diet (LFD) group (n=28), which was fed with low-fat diet as the control. After 16 weeks on diet, each diet group was divided into periodontitis (P) and control (C) groups. The P groups were induced for periodontitis by ligation with Porphyromonas gingivalis-adhered silk for 5 or 10 days, and the C groups were sham-ligated as the control. Visceral organs were resected and weighed. The organ weight percentage was calculated. Results Compared with the LFD group, the HFD group significantly upregulated the weight and weight percentage of visceral adipose tissue and spleen (P<0.05), upregulated the weight of liver and kidney (P<0.05), and down-regulated the weight percentage of liver and kidney (P<0.01). In the HFD group, the weight and weight percentage of spleen were downregulated in the P group (P<0.05), but were up-regulated in the 10-day group compared with the 5-day group (P<0.05). Conclusion Periodontitis can affect the general morphology of the viscera (especially spleen) in obese animal models. Pathological indications in terms of immunometabo-lism might be present in the correlation between obesity and periodontitis.

Key words: obesity, periodontitis, viscera, spleen, pathology

中图分类号:

R781.4

余挺,赵莉,章锦才,轩东英. 牙周炎对肥胖小鼠内脏重量和系数的影响[J]. 华西口腔医学杂志, 2018, 36(5): 514-520.

Ting Yu,Li Zhao,Jincai Zhang,Dongying Xuan. Impacts of periodontitis on visceral organ weight and weight percentage in obese mice[J]. West China Journal of Stomatology, 2018, 36(5): 514-520.

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参数	不控制主效应		控制主效应
参数	R值	P值	R值	P值
EWAT	0.927	<0.001	0.571	<0.001
EWATp	0.889	<0.001	0.219	0.093
PWAT	0.787	<0.001	0.482	<0.001
PWATp	0.772	<0.001	0.368	0.004
MWAT	0.847	<0.001	0.724	<0.001
MWATp	0.796	<0.001	0.605	<0.001
肝	0.533	<0.001	0.651	<0.001
肝p	-0.265	0.035	0.332	0.009
脾	0.239	0.057	-0.195	0.131
脾p	-0.207	0.100	-0.369	0.003
肾	0.765	<0.001	0.653	<0.001
肾p	-0.449	<0.001	0.066	0.614

参数	结扎期	HFD		LFD
参数	结扎期	P组	C组	P组	C组
EWAT/g	5 d	1.132 2±0.268 7^M	1.131 2±0.193 7^BM	0.219 8±0.028 2^N	0.234 1±0.029 3^N
	10 d	1.022 0±0.252 1^M	0.881 4±0.173 9^AM	0.145 0±0.075 3^XN	0.229 3±0.042 3^YN
EWATp/%	5 d	2.83±0.51^M	2.81±0.27^BM	0.77±0.08^N	0.83±0.09^N
	10 d	2.71±0.45^YM	2.29±0.32^AXM	0.53±0.27^XN	0.82±0.18^YN
PWAT/g	5 d	0.506 4±0.171 2^M	0.506 9±0.156 0^BM	0.089 2±0.029 6^BN	0.085 9±0.014 0^N
	10 d	0.587 9±0.460 9^M	0.352 2±0.127 5^AM	0.048 8±0.027 0^AXN	0.102 5±0.042 9^YN
PWATp/%	5 d	1.25±0.34^M	1.24±0.24^BM	0.31±0.09^BN	0.30±0.03^N
	10 d	1.50±1.01^M	0.90±0.24^AM	0.18±0.09^AXN	0.37±0.17^YN
MWAT/g	5 d	1.149 4±0.356 5^M	1.261 7±0.458 7^BM	0.494 4±0.048 7^BN	0.447 1±0.121 0^N
	10 d	1.015 0±0.505 2^M	0.810 2±0.203 8^AM	0.256 6±0.062 1^AXN	0.350 7±0.075 7^YN
MWATp/%	5 d	2.91±0.69^M	3.08±0.78^BM	1.73±0.10^BN	1.58±0.37^N
	10 d	2.62±1.00^M	2.10±0.39^AM	0.98±0.20^AN	1.25±0.28^N
肝/g	5 d	1.705 2±0.481 3	1.770 4±0.749 9	1.384 0±0.136 5	1.365 9±0.214 9
	10 d	1.480 6±0.334 0	1.450 7±0.171 3^M	1.392 7±0.241 1	1.237 5±0.155 0^N
肝p/%	5 d	4.27±0.93	4.32±1.32	4.86±0.60	4.84±0.61
	10 d	3.99±0.96^N	3.79±0.32^N	5.30±0.65^YM	4.42±0.63^XM
脾/g	5 d	0.103 7±0.021 7	0.105 5±0.019 7^AM	0.100 3±0.020 2	0.086 6±0.012 3^N
	10 d	0.115 5±0.041 1^X	0.189 0±0.048 6^BYM	0.112 5±0.042 1	0.097 3±0.021 5^N
脾p/%	5 d	0.27±0.08^N	0.27±0.05^A	0.35±0.07^M	0.31±0.03
	10 d	0.32±0.15^X	0.50±0.15^BYM	0.43±0.16	0.34±0.07^N
肾/g	5 d	0.283 1±0.046 5^M	0.280 9±0.034 2^M	0.231 4±0.025 7^N	0.221 3±0.030 7^N
	10 d	0.255 4±0.031 4	0.288 5±0.039 8^M	0.229 0±0.035 2	0.215 7±0.017 5^N
肾p/%	5 d	0.72±0.09^N	0.70±0.05^N	0.81±0.07^M	0.78±0.07^M
	10 d	0.69±0.08^N	0.75±0.06	0.88±0.13^M	0.77±0.05

参数	饲料		结扎		结扎期		合计
参数	HFD组	LFD组	P组	C组	5 d	10 d	合计
EWAT/g	1.041 7±0.239 6	0.209 3±0.056 0	0.703 1±0.489 8	0.667 4±0.423 6	0.735 9±0.486 4	0.632 5±0.419 4	0.685 0±0.454 0
EWATp/%	2.66±0.44	0.75±0.20	1.89±1.13	1.80±0.92	1.94±1.06	1.74±0.98	1.84±1.02
PWAT/g	0.488 3±0.268 3	0.081 6±0.035 0	0.337 9±0.349 2	0.282 8±0.207 2	0.323 3±0.242 2	0.297 5±0.327 7	0.310 4±0.286 2
PWATp/%	1.23±0.57	0.29±0.12	0.88±0.79	0.75±0.44	0.84±0.52	0.80±0.75	0.82±0.64
MWAT/g	1.056 5±0.418 6	0.383 2±0.120 8	0.769 7±0.489 9	0.757 2±0.450 2	0.888 2±0.483 0	0.646 2±0.423 9	0.763 3±0.466 0
MWATp/%	2.67±0.81	1.37±0.39	2.13±1.00	2.07±0.86	2.41±0.89	1.81±0.87	2.10±0.92
肝/g	1.601 7±0.483 1	1.345 0±0.191 7	1.503 4±0.348 4	1.475 4±0.455 2	1.579 0±0.501 5	1.399 8±0.246 7	1.489 4±0.402 3
肝p/%	4.10±0.94	4.86±0.67	4.55±0.93	4.31±0.88	4.54±0.94	4.31±0.87	4.43±0.91
脾/g	0.128 4±0.049 0	0.099 2±0.026 6	0.108 2±0.031 9	0.123 0±0.051 3	0.099 7±0.019 6	0.131 5±0.053 4	0.115 6±0.043 0
脾p/%	0.34±0.15	0.36±0.10	0.34±0.13	0.36±0.13	0.29±0.07	0.40±0.15	0.35±0.13
肾/g	0.277 0±0.038 9	0.224 3±0.027 2	0.252 2±0.041 0	0.255 7±0.045 6	0.257 7±0.044 4	0.250 2±0.042 0	0.253 9±0.043 0
肾p/%	0.71±0.07	0.81±0.09	0.76±0.11	0.75±0.06	0.75±0.08	0.76±0.10	0.76±0.09

参数	统计量	饲料	结扎	结扎期	饲料×结扎	饲料×结扎期	结扎×结扎期	饲料×结扎×结扎期
EWAT	F值	351.502	0.059	6.094	1.821	2.479	0.153	1.388
	P值	<0.001	0.810	0.017	0.183	0.121	0.697	0.244
EWATp	F值	549.513	0.071	7.400	5.999	1.434	0.272	3.745
	P值	<0.001	0.791	0.009	0.018	0.236	0.604	0.058
PWAT	F值	63.986	0.825	0.227	1.972	0.059	0.776	2.077
	P值	<0.000 1	0.368	0.635	0.166	0.808	0.382	0.155
PWATp	F值	75.595	0.978	0.124	3.437	0.004	0.830	3.342
	P值	<0.001	0.327	0.726	0.069	0.948	0.366	0.073
MWAT	F值	72.529	0.021	8.499	0.195	0.636	0.310	2.110
	P值	<0.001	0.886	0.005	0.661	0.428	0.580	0.152
MWATp	F值	71.504	0.137	14.856	0.588	0.106	0.186	3.407
	P值	<0.001	0.713	<0.001	0.447	0.746	0.668	0.070
肝	F值	6.951	0.125	2.907	0.287	1.188	0.355	0.012
	P值	0.011	0.725	0.094	0.594	0.280	0.554	0.915
肝p	F值	13.310	1.565	0.915	0.783	1.000	1.788	0.527
	P值	<0.001	0.216	0.343	0.380	0.322	0.187	0.471
脾	F值	13.452	2.112	13.743	10.704	5.139	4.835	5.266
	P值	<0.001	0.152	<0.001	0.002	0.027	0.032	0.026
脾p	F值	0.521	0.215	14.121	7.968	2.487	1.669	4.236
	P值	0.474	0.644	<0.001	0.007	0.120	0.202	0.044
肾	F值	36.965	0.048	0.663	2.455	0.122	0.852	1.243
	P值	<0.001	0.828	0.419	0.123	0.729	0.360	0.270
肾p	F值	24.120	1.035	0.845	5.591	0.149	0.001	4.246
	P值	<0.001	0.313	0.362	0.022	0.701	0.980	0.044

牙周炎对肥胖小鼠内脏重量和系数的影响

Impacts of periodontitis on visceral organ weight and weight percentage in obese mice

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