华西口腔医学杂志 ›› 2017, Vol. 35 ›› Issue (4): 437-441.doi: 10.7518/hxkq.2017.04.018

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孕期健康和环境暴露对牙发育的影响

万冕(), 周学东, 郑黎薇()   

  1. 口腔疾病研究国家重点实验室,国家口腔疾病临床研究中心,四川大学华西口腔医院,成都 610041
  • 收稿日期:2016-09-17 修回日期:2017-05-13 出版日期:2017-08-01 发布日期:2017-08-01
  • 作者简介:

    万冕,讲师,博士,E-mail:wan10167@hotmail.com

  • 基金资助:
    国家自然科学基金面上项目(81470711,81371136)

Effect of maternal health and prenatal environmental exposure factors on tooth development

Mian Wan(), Xue-dong Zhou, Liwei Zheng()   

  1. State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2016-09-17 Revised:2017-05-13 Online:2017-08-01 Published:2017-08-01
  • Supported by:
    National Natural Science Foundation of China, General Project (81470711, 81371136)

摘要:

牙发育是复杂信号网络调控的牙源性上皮和神经嵴来源牙源性间充质之间交互作用的结果,遗传因素及环境因素在此过程中均发挥重要作用。母体是胎儿生长发育的主要载体,孕期母体健康和环境暴露对胎儿和儿童牙发育具有较大影响。本文根据不同类型的孕期母体环境因素,重点从环境内分泌干扰物、多种化学物质的联合作用及母体健康等三个方面对胎儿和儿童牙发育的关键问题进行综述,探讨了孕期环境因素在釉质发育缺陷、磨牙切牙矿化不全、氟牙症、多生牙及先天性缺牙等牙发育异常中的作用,为从生命早期预防牙发育异常、评估牙发育异常风险、进行牙发育相关咨询、促进儿童口腔健康管理提供理论依据。

关键词: 牙发育, 孕期健康, 环境因素, 环境内分泌干扰物

Abstract:

Odontogenesis is a consequence of a complex series of reciprocal signal interactions between odontogenic epi-thelium and neural crest-derived odontotgenic mesenchyme. These interactions result from a complex interplay of genetic and environmental factors. Given that a fetus develops in the mother, maternal health and environmental exposures have a great influence on tooth development. In this review, we focused on the key issues in the developmental defects of teeth induced by various types of maternal environmental factors, including environmental endocrine disruptors, joint action of two or more chemical exposures, and maternal health status. This review also discussed the adverse effects of maternal environmental factors on tooth development. These effects include enamel developmental defects, molar incisor hypomineralization, dental fluorosis, hyperdontia and hypodontia. Overall, this review provides a theoretical basis for the prevention of tooth defects in early life, assessment of risks from developmental tooth defects, and advancement of pediatric oral health management.

Key words: odontogenesis, maternal health, environmental factors, environmental endocrine disruptors

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