华西口腔医学杂志

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牙槽骨垂直牵张后骨段颊向移位对牵张成骨早期的影响

孙明1 律娜1 黄代营2 陈松龄2 颜雨春1 张令达1   

  1. 1.安徽医科大学第一附属医院口腔科, 合肥230032; 2.中山大学第一附属医院口腔科, 广州510080
  • 收稿日期:2011-12-25 修回日期:2011-12-25 出版日期:2011-12-20 发布日期:2011-12-20
  • 通讯作者: 陈松龄,Tel:020-87755766
  • 作者简介:孙明(1979—),男,安徽人,主治医师,硕士
  • 基金资助:

    广东省科技厅科研基金资助项目(2009B05700025;2011-B010200008)

The impact of changing the buccal position of the transported bone on early bone formation after alveolar vertical distraction

Sun Ming1, Lü Na1, Huang Daiying2, Chen Songling2, Yan Yuchun1, Zhang Lingda1   

  1. 1. Dept. of Stomatology, The First Affiliated Hospital, Anhui Medical University, Hefei 230032, China; 2. Dept. of Stomatology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China
  • Received:2011-12-25 Revised:2011-12-25 Online:2011-12-20 Published:2011-12-20
  • Contact: Chen Songling,Tel:020-87755766

摘要:

目的研究牙槽骨垂直牵张成骨后,移动骨段一步颊向移位较大距离对牵张成骨的早期影响。方法自行研制双向牵张器。杂种犬8只,拔除双侧下颌前磨牙1个月后,骨切开放置牵张器,间歇7 d后以每天1 mm的速度牵张,垂直牵张高度为6 mm。垂直牵张完成后,每只犬的随机一侧作为实验侧,于牵张结束后第2天一步将移动骨段颊向移位3 mm,另一侧作为对照侧不改变移动骨段的颊向位置。7 d后处死动物并行墨汁灌注,进行临床检查,双能X线检查牵张区骨密度,组织学检查及图像分析血管面积比率。结果实验动物均能很好地耐受实验操作,实验侧移动骨段在垂直牵张后可较容易地颊向移位3 mm,实验侧与对照侧牵张区内都有新生骨组织生成。双能X线检查显示:实验侧与对照侧的平均骨密度无统计学差异。组织学检查显示:实验侧与对照侧有平行于牵张方向的血管生成,未见明显的血管破坏,图像分析血管面积比率无统计学差异。结论在一定范围内,牙槽骨垂直牵张后移动骨段一步颊向移位可对牵张区新生骨组织塑形,避免轴向移位。这种操作并没有明显破坏其早期的血管生成及成骨潜能。

关键词: 牵张成骨, 双向牵张器, 牙槽骨增高

Abstract:

Objective To assess the effects of 1-step method of changing the buccal position of the transported bone after distraction on early bone formation. Methods The custom-made bidirectional distraction devices were used. Total of 8 adult mongrel dogs were procured. The bilaterally mandible premolars were extracted. After 1 month, the complete osteotomy was performed and the devices were placed. The gradual distraction was started after 1 week latency at the rate of 1mm per day, total 6 mm in height was achieved. The 1-step method of changing the buccal position of the transported bone was performed the day after the vertical distraction period in one side of the animals, and the other side as the controlled side. All animals were killed after a 7 days consolidation. The vascular system was stained post mortem carbon ink perfusion to assess possible damages. Quantitative evaluations of bone density were performed with dual-energy X-ray absorptiometry(DEXA), analysis of the ratio of vascular square was conducted in a computer. Results All animals tolerated the procedures well. After vertical distraction, the tested side can be moved 3 mm in buccal direction. DEXA examination showed that the density of the distracted bone was no statistical difference in both the tested and the controlled side. Vascular damage was not observed, and there was no statistical difference in the ratio of vascular square by analyzing the histological section in computer. Conclusion In some extent, 1-step method of changing the buccal position of the transported bone after distraction can mold the regenerate bone to correct the axial displacement, without endangering early callus formation and vascularization.

Key words: distraction osteogenesis, bidirectional distractor, augmentation of alveolar bone