West China Journal of Stomatology

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Influence of or thodontic for ce on osteoproteger in and osteoproteger in ligand mRNA expr ession in the inflammatory per iodontal tissues

XIAO Li- wei1，2, CHEN Yang- xi3, BAI Ding3   

  1. 1. Center of Stomatology of The Second Xiangya Hospital, Central South University, Changsha 410011, China; 2. Key. Laboratory of Oral Biomedical Engineering of Ministry of Education, Sichuan University, Chengdu 610041, China; 3. Dept. of Orthodontics, West China College of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2007-10-25 Revised:2007-10-25 Online:2007-10-20 Published:2007-10-20
  • Contact: CHEN Yang- xi，Tel：028- 85503081

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Abstract:

Objective To explore certain principle of how osteoprotegerin（OPG） and osteoprotegerin ligand（OPGL） take part in the periodontal tissues remodeling under the combined influence of inflammation and orthodontic force. Methods The positive signals of OPG and OPGL mRNA were measured with in situ hybridzation after orthodontic tooth movement in the experimental periodontitis groups and control ones. Results The OPG and OPGL mRNA expression intensity in the experimental group showed difference from control. All their optical density index reached a peak in day 2, respectively. Conclusion OPG and OPGL play important roles in the periodontal reconstruction induced by inflammation irritation and orthodontic force, and complex interaction could exist between the two factors.

Key words: osteoprotegerin, osteoprotegerin ligand, periodontitis, orthodontic force

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