Abstract:

Objective To explore the coagulation indexes and offer a valuable reference for clinic therapy and prognosis in patients with oral squamous cell carcinomas（OSCCs）. Methods The indexes of prothrombin time（PT）, activated partial thromboplastin time（APTT）, thrombin time（TT） and fibrinogen（Fib）were detected by using automatic blood coagulation testing machine in 65 healthy people and 351 patients with OSCCs. All patients with OSCCs were divided into three groups included primary tumor, neck metastasis of lymph nodes and recurrence. The data were analysed by SPSS 11.0. Results The index of PT in patients with OSCCs was longer than that of healthy people. There was a significance between the control group and the group with the neck metastasis of lymph node or the recurrence group（P <0.01）. The time of APTT was shortened. Except for the group with the neck metastasis of lymph node and the recurrence group the distinctive difference existed in other groups（P<0.05）. There was no significance between two groups in the indexes of TT and Fib（P>0.05）. Conclusion PT and APTT may be the useful indexes for clinic therapy and prognosis in patients with oral squamous cell carcinomas.

Key words: oral carcinoma, squamous cell carcinoma, coagulation, recurrence