Advances in molecular mechanisms of bone invasion by oral cancer

doi:10.7518/hxkq.2021.02.015

Abstract

Abstract:

Bone invasion by oral cancer is a common clinical problem, which affects the choice of treatment and predicts a poor prognosis. Unfortunately, the molecular mechanism of this phenomenon has not been fully elucidated. Current studies have revealed that oral cancer cells modulate the formation and function of osteoclasts through the expression of a series of signal molecules. Many signal pathways are involved in this process, of which receptor activator of nuclear factor-κB ligand/receptor activator of nuclear factor-κB/osteoprotegerin signaling pathway attracted much attention. In this review, we introduce recent progress in molecular mechanisms of bone invasion by oral cancer.

Key words: oral cancer, bone invasion, molecular mechanism, osteoclast

CLC Number:

R 739.8

Liu Wei, Li Chunjie, Li Longjiang. Advances in molecular mechanisms of bone invasion by oral cancer[J]. West China Journal of Stomatology, 2021, 39(2): 221-226.

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