West China Journal of Stomatology ›› 2020, Vol. 38 ›› Issue (5): 583-588.doi: 10.7518/hxkq.2020.05.019

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Advances in oral bacteria influencing host epigenetic regulation

Mei Hongxiang(), Chen Yilin, Shi Peilei, Yang Sirui, Xu Xin, He Jinzhi()   

  1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2019-12-11 Revised:2020-06-02 Online:2020-10-01 Published:2020-10-14
  • Contact: He Jinzhi E-mail:978604542@qq.com;hejinzhi@scu.edu.cn
  • Supported by:
    The National Natural Science Foundation of China Youth Science Fund Project(81600874);The National Natural Science Foundation of China(81771099);The National Natural Science Foundation of China(81670978);Sichuan University Innovation and Entrepreneurship Training Program under Grants(C2018103959);Applied Basic Research Program of Sichuan Province Science and Technology Department(2020YJ0240)


Epigenetics refers to a steady change in the level of gene expression caused by non-DNA sequence changes. Microbes can modulate host inflammation through epigenetic pathways to evade or expend immune responses. As an important part of human microbes, oral bacteria also have various epigenetic regulation mechanisms to affect host inflammatory responses. This article reviews the common pathways of epigenetic regulation in microbe infection and the regulation of host epigenetics by using oral microbes to provide a reference for the study of epigenetic-related mechanisms in oral diseases.

Key words: oral bacteria, epigenetics, histones modification, DNA methylation, non-coding RNA

CLC Number: