West China Journal of Stomatology ›› 2020, Vol. 38 ›› Issue (5): 589-593.doi: 10.7518/hxkq.2020.05.020

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Role of bone morphogenetic protein 1/tolloid proteinase family in the development of teeth and bone

Xie Xudong(), Zhao Lei, Wu Yafei, Wang Jun()   

  1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Periodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2019-09-22 Revised:2020-06-15 Online:2020-10-01 Published:2020-10-14
  • Contact: Wang Jun E-mail:1107410744@qq.com;jwang316@sina.com
  • Supported by:
    The National Natural Science Foundation of China(81700980);The National Natural Science Foundation of China(81771077);Sichuan Province Science and Technology Support Program(2019YJ0097);China Postdoctoral Science Foundation(2017M623048);Postdoctoral Research Foundation of Sichuan University(2018SCU12018);Chengdu Science and Technology Support Program(2019-YF05-01078-SN)


The bone morphogenetic protein (BMP) 1/tolloid (TLD) proteinase family is a group of important metalloproteinases, which play key roles in the growth and development of tissues and organs via regulating the biosynthetic processing of the extracellular matrix. Clinical reports have revealed that mutations in the genes encoding BMP1/TLD proteinases lead to dentinogenesis imperfecta type Ⅰ, accompanied with osteogenesis imperfecta. Therefore, this proteinase family is essential for the development of hard tissues. In this study, we review the research progress in the function and mechanism of the BMP1/TLD proteinase family in the development of teeth and bone.

Key words: bone morphogenetic protein 1, gene knockout, dentinogenesis imperfecta, osteogenesis imperfecta, extracellular matrix

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