Role of bone morphogenetic protein 1/tolloid proteinase family in the development of teeth and bone

doi:10.7518/hxkq.2020.05.020

Abstract

Abstract:

The bone morphogenetic protein (BMP) 1/tolloid (TLD) proteinase family is a group of important metalloproteinases, which play key roles in the growth and development of tissues and organs via regulating the biosynthetic processing of the extracellular matrix. Clinical reports have revealed that mutations in the genes encoding BMP1/TLD proteinases lead to dentinogenesis imperfecta type Ⅰ, accompanied with osteogenesis imperfecta. Therefore, this proteinase family is essential for the development of hard tissues. In this study, we review the research progress in the function and mechanism of the BMP1/TLD proteinase family in the development of teeth and bone.

Key words: bone morphogenetic protein 1, gene knockout, dentinogenesis imperfecta, osteogenesis imperfecta, extracellular matrix

CLC Number:

Xie Xudong, Zhao Lei, Wu Yafei, Wang Jun. Role of bone morphogenetic protein 1/tolloid proteinase family in the development of teeth and bone[J]. West China Journal of Stomatology, 2020, 38(5): 589-593.

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