West China Journal of Stomatology

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Application of Raman spectroscopy in the stomatology

Xue Lili1, Yan Bing2, Li Yi3.   

  1. 1. Dept. of Stomatology, The First Affiliated Hospital of Xiamen University, Xiamen 361003, China; 2. Dept. of Otolaryngology Head and Neck Surgery, The First Affiliated Hospital of Xiamen University, Xiamen 361003, China; 3. State Key Laboratory of Oral Diseases, Dept. of Head and Neck Oncology, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2014-09-22 Revised:2015-01-10 Online:2015-04-01 Published:2015-04-01


Raman spectroscopy is an optical technology based on the theory of Raman scattering, which is generally used in the research of medical and biological science. Raman spectroscopy can be used to detect the molecular structures and components of proteins, lipids, DNA, and other biological molecules, and provide substantial information about molecules. Thus, Raman spectroscopy is generally considered a “molecular fingerprint”, and it has exceptional advantages in medical research. Moreover, this technique can reflect the changes in molecular structures and detect the alterations of chemical constituents in the samples. Raman spectroscopy, given its high sensitivity and specificity in the detection of the biological samples, has been successfully used to detect and diagnose diseases in numerous sites, such as skin, oral mucosa, breast, head, and neck. In this paper, we introduce the application of Raman spectroscopy in stomatology by conducting a review of the literature.

Key words: Raman spectroscopy, stomatology, diagnosis, clinical application