华西口腔医学杂志 ›› 2017, Vol. 35 ›› Issue (4): 427-432.doi: 10.7518/hxkq.2017.04.016

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巨噬细胞功能和炎症消退机制及与牙周炎关系研究进展

白林(), 辛月娇, 段丁瑜(), 徐屹   

  1. 口腔疾病研究国家重点实验室,国家口腔疾病临床研究中心,四川大学华西口腔医院牙周科,成都 610041
  • 收稿日期:2016-07-17 修回日期:2017-05-15 出版日期:2017-08-01 发布日期:2017-08-01
  • 作者简介:

    白林,硕士,E-mail:1559452901@qq.com

  • 基金资助:
    四川省科技厅科技支撑计划(2015SZ0137)

Advances in macrophage function and its anti-inflammatory and proresolving activity and role in periodontitis deve-lopment

Lin Bai(), Yuejiao Xin, Dingyu Duan(), Yi Xu   

  1. State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Dept. of Periodontology, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2016-07-17 Revised:2017-05-15 Online:2017-08-01 Published:2017-08-01
  • Supported by:
    Science and Technology Support Program of Sichuan Science and Technology Department (2015SZ0137).

摘要:

巨噬细胞是人体固有免疫系统中重要的组成部分,具有强大的识别、吞噬、清除细菌及外来异物的功能。牙周炎是一种以牙龈炎症和牙槽骨丧失为特征的慢性感染性疾病,是成年人失牙的主要病因。目前已经明确,牙周炎的组织破坏是由宿主对感染的免疫应答引起的,巨噬细胞作为宿主免疫应答的重要组成部分,在炎症的发生发展中起重要作用。近年研究显示,巨噬细胞在炎症消退过程中亦扮演着重要作用。本文就巨噬细胞在炎症的发生、发展及消退中的作用进行综述,并总结了其在牙周炎发展及治疗中可能的作用。

关键词: 巨噬细胞, 牙周炎, 极化, 胞葬, 促炎消散介质, 脂氧素

Abstract:

Macrophage plays an important role in human innate immune system. It has powerful functions, such as recog-nition, phagocytosis, and bacteria and foreign body removal. Periodontitis, which is a chronic infectious disease characterized by gum inflammation and bone loss, is a major cause of tooth loss in adults. Several studies demonstrated that periodontal tissue destruction is caused by the host immune response defending against infections. As an important part of host immune response, macrophage is also involved in periodontitis pathogenesis. Recently, anti-inflammatory and proresolving activities of macrophage was discovered. Thus, the complex function of macrophage in the occurrence, development, and resolution of inflammation and its potential role in periodontitis were reviewed.

Key words: macrophage, periodontitis, polarization, efferocytosis, proresolving mediators, lipoxin

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