间充质干细胞来源胞外囊泡在牙及颌面部组织再生中的研究与展望

doi:10.7518/hxkq.2022.01.002

华西口腔医学杂志 ›› 2022, Vol. 40 ›› Issue (1): 7-13.doi: 10.7518/hxkq.2022.01.002

间充质干细胞来源胞外囊泡在牙及颌面部组织再生中的研究与展望

廖立(), 田卫东()

口腔疾病研究国家重点实验室国家口腔疾病临床医学研究中心口腔转化医学教育部工程研究中心口腔再生医学国家地方联合工程实验室四川大学华西口腔医院创伤整形外科，成都 610041

收稿日期:2020-11-26 修回日期:2021-11-05 出版日期:2022-02-01 发布日期:2022-02-07
通讯作者: 田卫东 E-mail:lliao@scu.edu.cn;drtwd@sina.com
作者简介:廖立，副研究员，博士，E-mail：lliao@scu.edu.cn
基金资助:
国家自然科学基金(82071092);四川省重点研发项目(2019YFS0311)

Prospect on the application of mesenchymal stem cell-derived extracellular vesicles in the regeneration of dental and maxillofacial tissues

Liao Li(), Tian Weidong.()

State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Engineering Research Center of Oral Translational Medicine, Ministry of Education & National Engineering Laboratory for Oral Regenerative Medicine & Dept. of Traumatic and Plastic Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China

Received:2020-11-26 Revised:2021-11-05 Online:2022-02-01 Published:2022-02-07
Contact: Tian Weidong. E-mail:lliao@scu.edu.cn;drtwd@sina.com
Supported by:
The National Natural Science Foundation of China(82071092);Key Project of Sichuan Province(2019YFS0311);Correspondence: Tian Weidong, E-mail: drtwd@sina.com

摘要/Abstract

摘要：

胞外囊泡（EVs）是不同细胞间及多种组织间信号交流的重要途径，广泛参与组织发育、稳态维持和再生修复等过程。间充质干细胞（MSCs）分泌的EVs含有丰富的生物活性物质，是MSCs发挥促组织再生作用的重要分泌性成分之一。近年来，MSCs分泌的EVs（MSC-EVs）在牙及颌面组织修复再生中的研究取得快速进展。MSC-EVs已被证实可以有效促进牙及颌骨中干细胞和前体细胞的增殖、分化、存活、迁移，并加快血管神经再生，从而可应用于牙髓、牙周、颌骨、颞下颌关节及颌面软组织的再生。因为EVs具备免疫原性低、作用途径广、可规模化制备等优势，其临床应用潜力巨大。随着对EVs作用机理的深入探索和标准化制备及检测体系的建立，MSC-EVs治疗有望成为牙及颌面部组织再生的重要策略。

关键词: 胞外囊泡, 间充质干细胞, 牙, 颌骨, 再生

Abstract:

Extracellular vesicles (EVs) are the essential mediators of communication between different cells or tissues. EVs participate in the development, homeostasis, repair, and regeneration of tissues. Mesenchymal stem cells(MSCs) secrete a range of bioactive factors, which are important in MSC-mediated tissue regeneration. Great progress has been made in the research of EVs derived from MSCs (MSC-EVs) in the regeneration of dental and maxillofacial tissues. Emerging evidence confirmed that MSC-EVs can efficiently modulate the proliferation, differentiation, survival, and migration of stem or progenitor cells and stimulate the regeneration of the neurovascular system. MSC-EVs have been used in regenerating dental pulp, periodontium, jawbone, temporomandibular joint, and maxillofacial soft tissues. Having the advantages of low immunogenicity, versatile function, and suitability for large-scale production, EVs have excellent clinical application prospect. Along with investigations on molecular mechanisms of action and development of standard manufactory and testing systems, therapies u-sing MSC-EVs are promising strategies for regenerating dental and maxillofacial tissues.

Key words: extracellular vesicles, mesenchymal stem cells, tooth, jawbone, regeneration

中图分类号:

Q 254

廖立, 田卫东. 间充质干细胞来源胞外囊泡在牙及颌面部组织再生中的研究与展望[J]. 华西口腔医学杂志, 2022, 40(1): 7-13.

Liao Li, Tian Weidong.. Prospect on the application of mesenchymal stem cell-derived extracellular vesicles in the regeneration of dental and maxillofacial tissues[J]. West China Journal of Stomatology, 2022, 40(1): 7-13.

图/表 1

参考文献 44

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间充质干细胞来源胞外囊泡在牙及颌面部组织再生中的研究与展望

Prospect on the application of mesenchymal stem cell-derived extracellular vesicles in the regeneration of dental and maxillofacial tissues

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