不同源性外泌体在骨缺损修复中的研究进展

doi:10.7518/hxkq.2020.02.014

华西口腔医学杂志 ›› 2020, Vol. 38 ›› Issue (2): 193-197.doi: 10.7518/hxkq.2020.02.014

不同源性外泌体在骨缺损修复中的研究进展

刘士博, 刘显()

口腔疾病研究国家重点实验室国家口腔疾病临床医学研究中心四川大学华西口腔医院口腔颌面外科,成都 610041

收稿日期:2019-02-17 修回日期:2019-12-09 出版日期:2020-04-01 发布日期:2020-04-15
通讯作者: 刘显 E-mail:jssyliuxian@163.com
作者简介:刘士博,硕士,E-mail：1282652699@qq.com
基金资助:
国家自然科学基金(31400829);四川省科技创新团队项目(2017TD0016)

Review for different sources of exosomes in bone tissue engineering research

Liu Shibo, Liu Xian()

State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China

Received:2019-02-17 Revised:2019-12-09 Online:2020-04-01 Published:2020-04-15
Contact: Xian Liu E-mail:jssyliuxian@163.com
Supported by:
The National Natural Science Foundation of China(31400829);Science and Technology Innovation Team Project in Sichuan Province(2017TD0016)

摘要/Abstract

摘要：

外泌体是来自细胞内并通过多囊泡体与质膜融合后释放到细胞外环境的囊泡,直径为40~100 nm。外泌体富含多种生物活性物质,是细胞间信号传递、相互作用的重要物质载体,在组织修复及再生过程中发挥着重要作用。众多的研究表明,细胞分泌的外泌体具有调节免疫、促进细胞增殖分化、促进骨及血管再生的作用,在骨组织工程中发挥着越来越重要的作用。本综述分析骨环境中不同细胞来源的外泌体特征及生物学性能,总结其在骨缺损修复中的研究进展,并探讨其在骨组织工程中应用所面临的挑战及未来发展方向。

关键词: 外泌体, 骨缺损, 骨修复

Abstract:

Exosomes are 40-100 nm vesicles that are released into the extracellular environment upon the fusion of multivesicular bodies with the plasma membrane. The biologically cargoes transported by exosomes are diverse. Exosomes are important carriers of signal transmission and interaction between cells. Exosomes are believed to play an important role in tissue repair and bone regeneration. Studies have evaluated that exosomes secreted by cells play an increasingly significant roles in bone tissue engineering and have multiple functions, including regulating immunity, promoting cell proliferation and differentiation, enhancing bone regeneration and angiogenesis. The review analyzes the characteristics and biological properties of different cell-derived exosomes in the bone environment, summarizes their research progress in bone repair, and discusses the challenges and future directions for their application in bone tissue engineering.

Key words: exosome, bone defect, bone repair

中图分类号:

Q257

刘士博, 刘显. 不同源性外泌体在骨缺损修复中的研究进展[J]. 华西口腔医学杂志, 2020, 38(2): 193-197.

Liu Shibo, Liu Xian. Review for different sources of exosomes in bone tissue engineering research[J]. West China Journal of Stomatology, 2020, 38(2): 193-197.

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不同源性外泌体在骨缺损修复中的研究进展

Review for different sources of exosomes in bone tissue engineering research

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