细胞自噬在牙周炎中的作用与机制

doi:10.7518/hxkq.2019.04.016

华西口腔医学杂志 ›› 2019, Vol. 37 ›› Issue (4): 422-427.doi: 10.7518/hxkq.2019.04.016

细胞自噬在牙周炎中的作用与机制

莫龙义¹,贾小玥²,刘程程³,周学东²,徐欣²()

1.口腔疾病研究国家重点实验室国家口腔疾病临床医学研究中心四川大学华西口腔医院
2.口腔疾病研究国家重点实验室国家口腔疾病临床医学研究中心四川大学华西口腔医院牙体牙髓病科
3.口腔疾病研究国家重点实验室国家口腔疾病临床医学研究中心四川大学华西口腔医院牙周病科,成都 610041

收稿日期:2018-03-09 修回日期:2019-04-20 出版日期:2019-08-01 发布日期:2019-08-23
通讯作者: 徐欣 E-mail:xin.xu@scu.edu.cn
作者简介:莫龙义,硕士,E-mail：molongyi@126.com
基金资助:
国家自然科学基金(81600871);国家自然科学基金(81771099);四川省科技厅项目(2016JY0006);四川省科技厅项目(2017029)

Role of autophagy in the pathogenesis of periodontitis

Longyi Mo¹,Xiaoyue Jia²,Chengcheng Liu³,Xuedong Zhou²,Xin Xu²()

1.State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
2.State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
3.State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Periodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China

Received:2018-03-09 Revised:2019-04-20 Online:2019-08-01 Published:2019-08-23
Contact: Xin Xu E-mail:xin.xu@scu.edu.cn
Supported by:
The National Natural Science Foundation of China(81600871);The National Natural Science Foundation of China(81771099);Foundation of the Science and Technology Department of Sichuan Province(2016JY0006);Foundation of the Science and Technology Department of Sichuan Province(2017029)

摘要/Abstract

摘要：

牙周炎是由牙菌斑生物膜引起的牙周组织的慢性炎症性疾病。细胞自噬是宿主对抗细菌感染的有效武器。近年来研究发现,细胞自噬不仅可以促进感染细胞对细菌和毒素的清除,而且有助于抑制炎症反应,以维持细胞内环境稳态,与牙周炎的发生发展关系密切。本文从细胞自噬与牙周病原菌感染的相互作用,细胞自噬与免疫炎症反应的相互调控,以及细胞自噬与牙槽骨代谢的关系3个方面,对细胞自噬与牙周炎发生发展的关系进行综述,为深入地研究细胞自噬与牙周炎相关机制提供参考,为牙周炎防治的研究提供新的思路。

关键词: 牙周炎, 自噬, 免疫, 炎症

Abstract:

Periodontitis is a chronic inflammatory disease of periodontal tissues initiated by oral biofilm. Cellular autophagy is an effective weapon against bacterial infection. Recent studies have shown that autophagy not only promotes the removal of bacteria and toxins from infected cells, but also helps to suppress the inflammatory response to maintain the homeostasis of intracellular environment, which is closely related to the development of periodontitis. Here, we reviewed the relationship between autophagy and periodontitis from three aspects: the interactions between autophagy and periodontal pathogen infection, the regulation of autophagy and immune inflammatory responses, and the relationship between autophagy and alveolar bone metabolism. We aim to provide ideas for further study on the mechanisms of autophagy and periodontitis, and ultimately contribute to a better prevention and treatment of periodontitis.

Key words: periodontitis, autophagy, immunity, inflammation

中图分类号:

R781.4

莫龙义,贾小玥,刘程程,周学东,徐欣. 细胞自噬在牙周炎中的作用与机制[J]. 华西口腔医学杂志, 2019, 37(4): 422-427.

Longyi Mo,Xiaoyue Jia,Chengcheng Liu,Xuedong Zhou,Xin Xu. Role of autophagy in the pathogenesis of periodontitis[J]. West China Journal of Stomatology, 2019, 37(4): 422-427.

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细胞自噬在牙周炎中的作用与机制

Role of autophagy in the pathogenesis of periodontitis

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