微小RNAs在牙釉质发育过程中的表达和作用

doi:10.7518/hxkq.2017.03.018

摘要/Abstract

摘要：

微小RNAs（microRNAs）是一类内源性的短链非编码RNA,在转录后水平调控基因的表达,在各项生物发生过程中发挥重要的调控作用。牙釉质发育过程中任何信号的干扰和突变都可能导致牙釉质形成障碍。本文对miRNAs在牙釉质发育过程中的表达和作用机制进行综述。

关键词: 微小RNA, 釉质发育, 成釉细胞, 表达

Abstract:

microRNAs (miRNAs) are endogenous short, noncoding RNAs that can negatively regulate gene expression post-transcriptionally. miRNAs are involved in multiple developmental events in various tissues and organs, including dental enamel development. Any disruption during enamel development may result in inherited enamel malformations. This article reviews the expression and function of miRNAs in enamel development.

Key words: microRNAs, enamel development, ameloblast, expression

中图分类号:

R 780.2

周雅川, 周学东, 郑黎薇. 微小RNAs在牙釉质发育过程中的表达和作用[J]. 华西口腔医学杂志, 2017, 35(3): 328-333.

Yachuan Zhou, Xuedong Zhou, Liwei. Zheng. Expression and function of microRNAs in enamel development[J]. West China Journal of Stomatology, 2017, 35(3): 328-333.

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