关键词: 2型糖尿病, 慢性牙周炎, 福赛斯坦纳菌

Abstract:

Objective To study the prevalence of Tannerella forsythensis（T.forsythensis） in the subgingival plaque of type 2 diabetes, analyze the relationship between T.forsythensis and related factors, discuss the role of T.forsythensis in the chronic periodontitis and type 2 diabetes. Methods 160 subgingival plaque samples were collected from type 2 diabetic patients and pathogens genomic DNA were extracted by phenol and chloroform from plaque. T. forsythensis was detected by polymerase chain reaction, and Pearson correlation and Logistic regression analysis were used to analyze the relationship between T.forsythensis and systemic factors and periodontal status. Results The prevalence of T. forsythensis in mild, moderate, severe periodontitis group was 47.82%, 48.71%, 67.39% respec - tively, and the prevalence was higher in the severe periodontitis group than in mild, moderate group（P<0.05）. There was no T.forsythensis in 6 diabetic patients with healthy periodontium. Logistic regression analysis illustrated that the prevalence of T.forsythensis was associated with simplified oral hygiene index（OHI-S） and diabetic duration（OR= 1.947, OR=0.873）. Conclusion The prevalence of T.forsythensis in type 2 diabetes with chronic periodontitis was related with oral hygiene, periodontal status and diabetic duration.

Key words: type 2 diabetes, chronic periodontitis, Tannerella forsythensis