Abstract: Objective To test the corrosion behavior of three kinds of dental casting alloys and to investigate the effect of the released metal ions on the DNA damage of dog buccal mucosal cells. Methods Three kinds of frequently used dental casting alloys were used to make full crowns for dogs. The concentration of the released metal ions was measured after the restoration of 2 weeks, 1 month, 2 months and 3 months. The DNA damage of buccal mucosal cells was studied by the method of SCGE. Results The metal ions released from NiCr and NiCrBe were detected in buccal mucosal cells while the amount of the ions released from noble alloy（gold 58%）was too small to be detected. The DNA damage of mucosal cells increased after restoration of NiCr and NiCrBe crowns. Conclusion The noble alloy（gold 58%）is most corrosion resistant of the three alloys and has good biocompatibility. The NiCr and NiCrBe are prone to corrode and have cytotoxicity to cells.

Key words: dentalcastingalloy, ionreleasing, buccalmucosalcells, DNA