Abstract:

Objective　To investigate the association between FcγreceptorⅡAgene polymorphism and susceptibility to chron- ic periodontitis in ChineseHan nationality.Methods　DNAsampleswere collectedwith buccal swabs from63 patientswith severe chronic periodontitis(CP), 103 patients with mild to moderate CP and 80 healthy individuals as control. Polymorphism in Fcγre- ceptorⅡA gene cluster was analyzed with PCR-SSP. The genotype distribution and allele frequency among different groups were compared.Results　It was found that the frequency of FcγRIIA-R/R131 genotype was significantly higher in patients with severe CP (19·05%) compared to that of the healthy controls (P<0·012 5).Conclusion　The FcγRIIA-R/R131 genotype may be one of the contributors for the increased susceptibility to severe CP in Chinese Han nationality.

Key words: FcγreceptorⅡA, chronic periodontitis, gene polymorphism