Efficacy of minocycline hydrochloride combined with flap surgery for chronic periodontitis: a Meta-analysis

doi:10.7518/hxkq.2018.04.013

Abstract

Abstract:

Objective This study aimed to evaluate the efficacy of 2% minocycline hydrochloride combined with flap surgery in the treatment of chronic periodontitis. The superiority of this therapy to simple flap surgery was also explored. Methods We searched the databases of CNKI, VIP, Wanfang, Chinese Biomedical Literature, PubMed, ScienceDirect, and Embase from inception to July 2017. Two reviewers independently screened literature, extracted data, and evaluated the bias risk of included studies. Then, Meta-analysis was performed using RevMan 5.3 software. Results A total of seven randomized controlled trials involving 217 patients were included. Meta-analysis showed that, in two groups, the changes in probing depth (PD) [MD=-0.55, 95%CI (-0.84, -0.26), P=0.000 2] and plaque index [MD=-0.08, 95%CI (-0.15, -0.01), P=0.03] at 3 and 6 months of PD [MD=-0.62, 95%CI (-1.04, -0.21), P=0.003] had statistically significant difference (P<0.05). The clinical attachment loss (CAL) [MD=-0.21, 95%CI (-0.47, 0.04), P=0.10] had no statistically significant difference after 3 months (P>0.05), but the improvement in CAL was significantly improved by minocycline hydrochloride combined with flap therapy. Conclusion Periodontal flap combined with minocycline adjuvant therapy for chronic periodontitis is effective in short-term observations.

Key words: minocycline hydrochloride, chronic periodontitis, flap surgery, Meta-analysis

CLC Number:

R782

Yuanliang Bai, Taijing Zheng, Zhiwei Zhang, Yi Gan, Jiao Huang. Efficacy of minocycline hydrochloride combined with flap surgery for chronic periodontitis: a Meta-analysis[J]. West China Journal of Stomatology, 2018, 36(4): 421-427.

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纳入研究	例数（T/C）	年龄/岁	干预措施		随访时间/月	纳入时PD/mm	主要结局指标
纳入研究	例数（T/C）	年龄/岁	T	C	随访时间/月	纳入时PD/mm	主要结局指标
王岩等^[23]	8/7	35~72	FM+SRP	FO+SRP	3	≥5	PD+CAL+PI
李启艳等^[19]	13/13	40~56	FM+SRP	FO+SRP	6	≥5	PD+CAL
赵曼等^[21]	8/7	35~72	FM+SRP	FO+SRP	3	≥5	PD+CAL+PI
葛少华等^[22]	23/23	36~64	FM+SRP	FO+SRP	3	5≤PD≤10	PD +PI
粟立平^[18]	8/7	35~72	FM+SRP	FO+SRP	3	≥5	PD+CAL+PI
Abbas等^[20]	30/30	30~50	FM+SRP	FO+SRP	6	≥6	PD+CAL+PI
Jung等^[24]	20/20	43~69	FM+SRP	FO+SRP	6	≥6	PD+CAL+PI

纳入研究	随机方法	盲法	分配隐藏	结果数据的完整性	选择性报告研究结果	其他偏倚来源
王岩等^[23]	随机数字	不清楚	是	完整	否	不清楚
李启艳等^[19]	随机数字	不清楚	是	完整	否	不清楚
赵曼等^[21]	随机数字	不清楚	是	完整	否	不清楚
葛少华等^[22]	不清楚	双盲	是	完整	否	不清楚
粟立平^[18]	随机数字	不清楚	不清楚	完整	否	不清楚
Abbas等^[20]	丢硬币	是	是	完整	否	不清楚
Jung等^[24]	不清楚	双盲	是	完整	否	不清楚