West China Journal of Stomatology ›› 2018, Vol. 36 ›› Issue (4): 421-427.doi: 10.7518/hxkq.2018.04.013

• Orginal Article • Previous Articles     Next Articles

Efficacy of minocycline hydrochloride combined with flap surgery for chronic periodontitis: a Meta-analysis

Yuanliang Bai1,2(), Taijing Zheng2,3, Zhiwei Zhang1,4, Yi Gan2,4, Jiao Huang1,2()   

  1. 1. Dept. of Periodontics, Affiliated Stomatology Hospital, Chongqing Medical University, Chongqing 400015, China
    2. Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences, Chongqing 400015, China
    3. Dept. of Stomatology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China
    4. Chongqing Medical University, Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing 400015, China
  • Received:2018-03-05 Revised:2018-05-13 Online:2018-08-01 Published:2018-08-01
  • Supported by:
    Key Funding Projects of Chongqing Municipal Health Planning Commission (2015ZDXM018);Project Support Project of Innovation Team Construction in Chongqing University (CXTDG201602006)


Objective This study aimed to evaluate the efficacy of 2% minocycline hydrochloride combined with flap surgery in the treatment of chronic periodontitis. The superiority of this therapy to simple flap surgery was also explored. Methods We searched the databases of CNKI, VIP, Wanfang, Chinese Biomedical Literature, PubMed, ScienceDirect, and Embase from inception to July 2017. Two reviewers independently screened literature, extracted data, and evaluated the bias risk of included studies. Then, Meta-analysis was performed using RevMan 5.3 software. Results A total of seven randomized controlled trials involving 217 patients were included. Meta-analysis showed that, in two groups, the changes in probing depth (PD) [MD=-0.55, 95%CI (-0.84, -0.26), P=0.000 2] and plaque index [MD=-0.08, 95%CI (-0.15, -0.01), P=0.03] at 3 and 6 months of PD [MD=-0.62, 95%CI (-1.04, -0.21), P=0.003] had statistically significant difference (P<0.05). The clinical attachment loss (CAL) [MD=-0.21, 95%CI (-0.47, 0.04), P=0.10] had no statistically significant difference after 3 months (P>0.05), but the improvement in CAL was significantly improved by minocycline hydrochloride combined with flap therapy. Conclusion Periodontal flap combined with minocycline adjuvant therapy for chronic periodontitis is effective in short-term observations.

Key words: minocycline hydrochloride, chronic periodontitis, flap surgery, Meta-analysis

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