West China Journal of Stomatology ›› 2025, Vol. 43 ›› Issue (1): 98-105.doi: 10.7518/hxkq.2024.2024241
• Clinical Research • Previous Articles Next Articles
Li Dandan(), Yu Zhujun, Nie Cheng, Zou Zixin, Wang Jianli(
)
Received:
2024-06-25
Revised:
2024-10-25
Online:
2025-02-01
Published:
2025-01-22
Contact:
Wang Jianli
E-mail:1126468651@qq.com;wangjianli0804@163.com
Supported by:
CLC Number:
Li Dandan, Yu Zhujun, Nie Cheng, Zou Zixin, Wang Jianli. Evaluation and analysis of efficacy in bisphosphonate treatment of chronic nonbacterial osteomyelitis[J]. West China Journal of Stomatology, 2025, 43(1): 98-105.
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Tab 3
The effect of dose and frequency of administration of pamidronate on efficacy
给药剂量 | 给药频率 | 样本数/例 | 平均完全缓解率/% | ||
---|---|---|---|---|---|
临床表现 | 实验室检查 | 影像学检查 | |||
15 mg | 每3月1疗程 | 6 | 100 | 100 | 100 |
30~60 mg | 每月1疗程 | 43 | 90.7 | 90.7 | 90.7 |
30 mg | 每3月1次 | 1 | 100 | 100 | 100 |
45 mg | 单次 | 1 | 100 | 100 | 100 |
60 mg | 单次 | 1 | 100 | 100 | 100 |
1 mg/kg | 单次 | 1 | 100 | 100 | 100 |
每3月1次 | 6 | 100 | 100 | 100 | |
每3月1疗程 | 40 | 77.5 | 82.35 | 65 | |
每月1次 | 32 | 100 | 100 | 100 | |
每月1疗程 | 86 | 75.58 | 75.58 | 75.58 | |
1.5 mg/kg | 每月1次 | 7 | 57.14 | 57.14 | 57.14 |
0.5~1 mg/kg* | 单次 | 1 | 100 | 100 | 100 |
每月1次 | 24 | 100 | 100 | 100 | |
每6月1疗程 | 1 | 100 | 100 | 100 | |
每3月1疗程 | 164 | 76.83 | 75 | 76.22 |
Tab 4
The effect of dose and frequency of others on efficacy
药物类型 | 给药剂量 | 给药频率 | 样本数/例 | 临床表现、实验室检查、影像学检查平均完全缓解率/% |
---|---|---|---|---|
阿仑膦酸钠 | 10 mg | 单次 | 1 | 100 |
35 mg | 每周1次 | 1 | 100 | |
40 mg | 每日1次 | 1 | 100 | |
70 mg | 每周1次 | 3 | 66.67 | |
1 mg/kg | 每周1次 | 1 | 100 | |
1.5 mg/kg | 每周1次 | 1 | 100 | |
唑来膦酸钠 | 0.09 mg/kg | 每月1次 | 29 | 65.52 |
0.025 mg/kg | 每3月1次 | 10 | 80 | |
奈立膦酸钠 | 100 mg | 每日1次 | 1 | 100 |
2 mg/kg | 每3月1次 | 12 | 66.67 | |
伊班膦酸钠 | 6 mg | 每日1次 | 11 | 100 |
利塞膦酸钠 | 35 mg | 每周1次 | 1 | 100 |
奥帕膦酸钠 | 50~100 mg | 每日1次 | 3 | 0 |
Tab 5
Approved uses of BP
药物类型 | 适应证 | 批准国家 | 给药方案 |
---|---|---|---|
帕米膦酸钠 | 恶性肿瘤相关高钙血症 | 中国、美国、欧盟、日本 | 静滴,每疗程至少间隔7 d。1)中国、欧盟:总剂量15~90 mg,单次或按总剂量分成2~4次,每日1次;2)美国:总剂量60~90 mg,单次;3)日本:总剂量30~45 mg,每日1次 |
癌症骨转移性疼痛 | 中国、美国、欧盟、日本 | 静滴。1)中国:30~90 mg/次,每4周1次或90 mg/次,每3周1次;2)欧盟、美国:90 mg/次,每4周1次或90 mg/次,每3周1次;3)日本:90 mg/次,每隔4周1次 | |
Paget’s病 | 欧盟、美国 | 静滴,每疗程至少间隔6月。1)欧盟:①总剂量180 mg:30 mg/次,每周1次或60 mg/次,每2周1次;②总剂量210 mg:首次30 mg,后60 mg/次,每2周1次;2)美国:30 mg/次,每日1次,连续3 d | |
成骨不全 | 日本 | 静滴,每日剂量≤60 mg,连续3 d为1疗程。1)<2岁:0.5 mg/kg/次,每日1次,每隔2月1疗程;2)≥2岁且<3岁:0.75 mg/kg/次,每日1次,每隔3月1疗程;3)≥3岁:1 mg/kg/次,每日1次,每隔4月1疗程 | |
阿仑膦酸钠 | Paget’s病 | 美国 | 口服:40 mg/次,每日1次,连续6月 |
骨质疏松 | 中国、美国、欧盟、日本 | 口服。1)中国、美国、欧盟:70 mg/次,每周1次或10 mg/次,每日1次;2)日本:35 mg/次,每周1次或5 mg/次,每日1次 | |
唑来膦酸钠 | 恶性肿瘤相关高钙血症 | 中国、美国、欧盟、日本 | 静滴:4 mg/次,单次或再次至少间隔7 d |
癌症骨转移性疼痛、多发性骨髓瘤 | 中国、美国、欧盟、日本 | 静滴:4 mg/次,每3~4周1次 | |
Paget’s病 | 中国、美国、欧盟 | 静滴:5 mg/次,每次至少间隔1年 | |
骨质疏松 | 中国、美国、欧盟、日本 | 静滴:5 mg/次,每年1次 | |
伊班膦酸钠 | 恶性肿瘤相关高钙血症 | 中国、欧盟 | 静滴:2~4 mg/次,单次 |
癌症骨转移性疼痛 | 中国、欧盟 | 静滴。1)中国:4~6 mg/次,每3~4周1次;2)欧盟:6 mg/次,每3~4周1次;口服:欧盟:50 mg/次,每日1次 | |
骨质疏松 | 中国、美国、欧盟、日本 | 静滴。1)中国:2 mg/次,每3月1次;2)美国:3 mg/次,每3月1次;3)日本:1 mg/次,每月1次。口服:1)中国、美国、欧盟:150 mg/次,每月1次;2)日本:100 mg/次,每月1次 | |
利塞膦酸钠 | Paget’s病 | 美国、欧盟、日本 | 口服。1)美国、欧盟:30 mg/次,每日1次,连续2月;2)日本:17.5 mg/次,每日1次,连续2月 |
骨质疏松 | 中国、美国、欧盟、日本 | 口服。1)中国、美国、欧盟:5 mg/次,每日1次或35 mg/次,每周1次或75 mg/次,每月连续2 d或150 mg/次,每月1次;2)日本:2.5 mg/次,每日1次或17.5 mg/次,每周1次或75 mg/次,每月1次 |
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