Systematic review of factors related to quality of life in patients with oral cancer: a systematic review

doi:10.7518/hxkq.2024.2023373

Abstract

Abstract:

Objective This study aims to evaluate factors related to quality of life of patients with oral cancer. Methods CNKI, Wanfang, VIP, CBM, Pubmed, Medline, Web of Science, Embase, and The Cochrane Library were searched up to May 2023 for studies that evaluated the quality of life of patients with oral cancer. All the included studies were independently selected, extracted, and rated by two researchers, and results are summarized by qualitative analysis. Results Twenty-four articles on 2 717 patients were included. Factors related to the quality of life of patients with oral cancer mainly included age, tumor TNM stage, radiochemotherapy, and gender, which could be summarized into three aspects: personal factors, disease-related factors, and surgical factors. More than five studies reported on the analysis of age, gender, tumor TNM stage, pathological stage, neck dissection method, marital status, recurrence, smoking, education le-vel, etc. The results are relatively consistent. Conclusion The incidence of oral cancer increases, and many factors affected the quality of life. The included literature is a cross-sectional study, and the sample size is limited. The causal relationship between relevant factors and quality of life should be verified using large sample sizes.

Key words: oral cancer, quality of life, related factors, systematic review

CLC Number:

R739.8

Liu Mei, Shi Xinglian, Li Zhezhen, Jiang Jianhong. Systematic review of factors related to quality of life in patients with oral cancer: a systematic review[J]. West China Journal of Stomatology, 2024, 42(4): 486-493.

Figures/Tables 5

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文献	研究地点	研究类型	例数	男性	女性	相关因素	AHRQ总分
刘静等^[7]2022	湖南省	横断面	389	354	35	1、5、8	8
石巧灵等^[8]2022	河南省	横断面	71	51	20	3、4、5、6、7、8、9、10	8
李海朋^[9]2022	河南省	横断面	94	69	25	3、4、5、6、8、9	9
原露露等^[10]2020	辽宁省	横断面	230	134	96	2、3、8、11、12	7
林莉等^[11]2019	重庆市	横断面	90	50	40	7、14、15	9
易梅等^[12]2018	四川省	横断面	103	62	41	1、5、6、7、8	8
肖兵^[13]2018	湖北省	横断面	73	38	35	1、5、18	8
田露莉等^[14]2018	安徽省	横断面	113	69	44	6、7、8	8
秦帅华等^[15]2018	河南省	横断面	85	55	30	1、4、7	8
秦帅华等^[16]2018	河南省	横断面	126	73	53	1、4、6、7、8、12、16、17、19、20	8
黄泽浩^[17]2018	广东省	横断面	112	81	31	1、4、5、7、12、21	8
鲁旭飞等^[18]2017	山东省	横断面	57	41	16	3、4、8	8
柳渊等^[19]2014	新疆维吾尔自治区	横断面	85	57	28	3、4、5、6、8、9	8
韩永洁等^[20]2014	青海省	横断面	166	86	80	6、7、12、16、22	8
王维等^[21]2013	广东省	横断面	65	40	25	4、5、12、14	8
严颖彬等^[22]2012	天津市	横断面	55	29	26	12、16、19、22	7
de Melo等^[23]2019	巴西	横断面	102	67	35	5、12、13	9
de Melo等^[24]2018	巴西	横断面	102	67	35	2、5、14	8
Yan等^[25]2017	北京市	前瞻性	71	38	33	1、8	9
Yang等^[26]2016	河南省	横断面	61	55	6	1、2、4、8	8
Wells等^[27]2016	英国	横断面	280	204	76	1、2、3、16、19	9
Herce-Lopez等^[28]2013	西班牙	横断面	60	49	11	1、2、4、7	9
Dwivedi等^[29]2012	英国	横断面	55	36	19	1、8	9
Tahani等^[30]2017	伊朗	横断面	72	35	37	1、4、6、14、16	9

影响因素		文献数
个人因素	年龄	12^{[7,12-13,15-17, 25-30]}
	婚姻状况	7^{[10,16-17,20-23]}
	是否吸烟	6^{[8-10,18-19,27]}
	性别	5^{[10,24,26-28]}
	文化程度	5^{[16,20,22,27,30]}
	术前是否合并其他疾病	3^[16,22,27]
	居住地	1^[10]
	收入水平	1^[16]
手术相关因素	是否放化疗	11^{[8-9,15-19,21,26,28,30]}
	颈清方式	9^{[8,11-12,14-17,20,28]}
	手术方式	4^{[11,21,24,30]}
	术后缺损范围	2^[20,22]
	手术次数	1^[16]
	住院时间	1^[13]
	住院费用	1^[17]
疾病相关因素	肿瘤TNM分期	12^{[7-10,12,14,16,18-19,25-26,29]}
	病理分期	10^{[7-9,12-13,17,19,21,23-24]}
	是否复发	8^{[8-9,12,14,16,19-20,30]}
	浸润深度	3^[8-9,19]
	是否按时复诊	1^[11]
	颞下颌关节疼痛	1^[23]
	术后是否进行功能锻炼	1^[8]

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