West China Journal of Stomatology ›› 2019, Vol. 37 ›› Issue (3): 314-319.doi: 10.7518/hxkq.2019.03.017

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Human mycobiome and diseases

Xin Shen1,Yufei Yao1,Jiyao Li2,Yan Li1()   

  1. 1.State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
    2.State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Conservative Dentistry and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2018-12-21 Revised:2019-02-19 Online:2019-06-01 Published:2019-06-12
  • Contact: Yan Li E-mail:feifeiliyan@163.com
  • Supported by:
    The National Natural Science Foundation of China(81771085);Key Projects of Sichuan Provincial Health and Family Planning Commission(16ZD021)

Abstract:

The proportion of mycobiome is less than 1% of human microbiome. However, fungal community plays a key role in human health and diseases. With high-throughput sequencing applications, the structure and composition of mycobiome in the mouth, lung, gut, vagina, and skin have been analyzed, and the role of microbiome in diseases has been investigated. Mycobiome also influences the composition of bacteriome and includes key species that maintain the structure and function of microbial communities. Fungi also influence host immune responses. In this review, we summarized the mycobiome composition at various sites and different diseases and the interactions between fungi-bacteria and fungi-host.

Key words: mycobiome, diseases, bacteriome, interaction, hostimmune response

CLC Number: