Retrospective analysis of adverse drug reactions in stomatology hospital from 2014 to 2016

doi:10.7518/hxkq.2017.06.012

Abstract

Abstract:

Objective This study aims to investigate the characteristics and general rules of adverse drug reactions (ADR) in a 3A-grade stomatology hospital for safe and rational drug use in clinical stomatology. Methods We retrospectively ana-lyzed 52 ADR cases (1:1.36, males:females) reported in the West China Hospital of Stomatology of Sichuan University from 2014 to 2016 in terms of gender and age distributions, drug categories, and clinical manifestations. Results Eight kinds of drugs and antibiotics were predominately used [24 cases, 46.15% (24/52)], followed by nutrition drugs and antitumor drugs. Cephalosporin was the leading antibiotic drug associated with ADR [20 cases, 83.33% (20/24)]. Intravenous infusion was the most common route of drug administration [49 cases, 94.23% (49/52)]. The most common manifestations of the ADR were damages of the skin and its appendages and lesions of the digestive and nervous systems. Conclusion Streng-thening the ADR monitoring system and further management should be implemented to alleviate ADR in stomatology hospitals.

Key words: stomatology hospital, adverse drug reac-tion, analysis, monitoring

CLC Number:

R988.2

Jia Li, Jianli Wang, Ke Zhao, Shaofeng Zhao. Retrospective analysis of adverse drug reactions in stomatology hospital from 2014 to 2016[J]. West China Journal of Stomatology, 2017, 35(6): 625-628.

Figures/Tables 4

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References 9

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年龄/岁	病例/n			构成比/%
年龄/岁	男	女	合计	构成比/%
≤18	7	0	7	13.46
18~	9	12	21	40.38
31~	2	8	10	19.23
50~75	4	10	14	26.92
合计	22	30	52	100

药品分类	ADR例数	构成比/%
抗菌药物	24	46.15
营养药物	11	21.15
抗肿瘤药物	7	13.46
中枢神经系统药物	3	5.77
中成药	3	5.77
调节水电解质及其酸碱平衡药物	2	3.85
消化系统药物	1	1.92
局部麻醉药物	1	1.92
合计	52	100

药品种类	具体药物（病例数）	总病例数/n	构成比/%
头孢菌素类	头孢呋辛钠（14）,头孢曲松（6）	20	83.33
硝基咪唑类	奥硝唑（3）	3	12.50
青霉素类	美洛西林钠舒巴坦钠（1）	1	4.17
合计		24	100

涉及器官和/或系统	例次*	构成比/%	主要临床表现
皮肤及附件	24	40.68	过敏性皮炎,皮疹,斑丘疹,红斑疹,瘙痒
消化系统	11	18.64	恶心,呕吐,腹泻
中枢和外周神经	8	13.56	头痛,头晕,癫痫发作,局部麻木
全身性	7	11.86	寒战,苍白,发热,全身疼痛,变态反应
心血管系统	4	6.78	心悸,血压升高
呼吸系统	3	5.08	呼吸困难,胸闷
造血系统损害	2	3.39	白细胞减少,粒细胞减少
合计	59	100

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