West China Journal of Stomatology

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Relationship between transforming growth factor-β1 and interleukin-10 single nucleotide polymorphism and susceptibility of recurrent aphthous ulcer

Zhang Jing1, Sha Jingjing2, Gong Juan1   

  1. 1. Dept. of Endodontic Disease, Stomatological Hospital of Ningxia Medical University General Hospital, Yinchuan 750004, China; 2. Graduate School of Ningxia Medical University, Yinchuan 750004, China
  • Online:2016-02-01 Published:2016-02-01


Objective  To explore the possible relationship between recurrent aphthous ulcer (RAU) and single nucleotide polymorphism (SNP) of transforming growth factor-β1 (TGF-β1)-509T/C and interleukin-10 (IL-10)-1082A/G sites. Methods  A total of 138 RAU patients were recruited for this study. The control group consisted of 124 subjects. TGF-β1-509T/C and IL-10-1082A/G sites were detected by restriction fragment length polymorphism-polymerase chain reaction (RFLP-PCR) and sequence specific primer-polymerase chain reaction (SSP-PCR). Relative risk ratios were estimated by odds ratios (OR) and 95% confidence interval (95%CI). Results  Significant differences were found in the genotype frequencies or allele frequencies of TGF-β1-509T/C and IL-10-1082A/G sites between the RAU patients and controls (P<0.05). CT genotype (OR=1.231, 95%CI=0.702–2.160), TT genotype (OR=2.482, 95%CI=1.250–4.927), and T allele (OR=1.465, 95%CI=1.036–2.074) at the TGF-β1-509 site exhibited high risks. AG genotype (OR=1.391, 95%CI=0.808–2.396), GG genotype (OR=4.165, 95%CI=1.944–8.924), and G allele (OR=2.134, 95%CI=1.474–3.089) at the IL-10-1082A/G site also showed high risks. Conclusion  TGF-β1-509T/C and IL-10-1082A/G sites are associated with the risk of RAU. The TGF-β1 gene-509T allele and IL-10 gene-1082G allele may serve as genetic determinants for RAU.

Key words: transforming growth factor-β1, interleukin-10, single nucleotide polymorphism, recurrent aphthous ulcer