Abstract:

Objective  To assess the efficacy of Dexamethasone(DM) pericoronal injection for the control of swelling and trismus caused by impacted mandibular third molars extraction. Methods  Cochrane, PUBMED, EMBASE and CBM were searched for eligible studies. Hand-searching included references of the included studies and Chinese den-tal journals. Risk of bias of the included studies was assessed by two reviewers independently using Cochrane Colla-boration’s tool, and data extraction was done by them. Meta-analysis was delivered with Revman 5.1. Results  Seven randomized controlled trials, involving 684 participants, were included. Six of them had moderate risk of bias and one had high risk of bias. Meta-analysis showed that DM pericoronal injection could relieve trismus by 6.77 mm(P=0.02) within 1-2 days after the surgery. It could also reduce 51% of the risk of moderate-severe trismus(P<0.000 01) and could significantly control facial swelling(P<0.05). There was no differences between 4 mg and 8 mg DM(P>0.05). Conclusion    Periodontal injection of 4-5 mg DM could control facial swelling and trismus following impacted mandi-bular third molar extraction. But more randomized controlled trials are needed.

Key words: impacted tooth, tooth extraction, Dexamethasone, Meta-analysis, systematic review