基于口腔特殊环境的水凝胶创面敷贴设计策略

doi:10.7518/hxkq.2024.2024262

华西口腔医学杂志 ›› 2024, Vol. 42 ›› Issue (6): 689-698.doi: 10.7518/hxkq.2024.2024262

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基于口腔特殊环境的水凝胶创面敷贴设计策略

许瑞¹(), 潘钊², 邹多宏³()

^1.安徽医科大学口腔医学院，安徽医科大学附属口腔医院，安徽省口腔疾病研究重点实验室，合肥 230032
^2.中国科学院杭州医学研究所，杭州 310022
^3.上海交通大学医学院附属第九人民医院口腔外科，上海交通大学口腔医学院，国家口腔医学中心，国家口腔疾病临床医学研究中心，上海市口腔医学重点实验室，上海 200011

收稿日期:2024-07-14 修回日期:2024-08-03 出版日期:2024-12-01 发布日期:2024-11-29
通讯作者: 邹多宏 E-mail:dentistxr@126.com;zouduohongyy@163.com
作者简介:许瑞，口腔颌面外科学博士，安徽医科大学副教授，硕士研究生导师。主要研究方向为纳米技术在口腔鳞癌诊治及软硬组织修复中的应用。主持省厅级、校级科研课题3项，发表SCI论文11篇，其中近5年以第一作者（含共同第一作者）在Biomaterials、Analytical Chemistry、Chemical Engineering Journal、ACS Applied Materials & Interfaces、Sensors and Actuators：B. Chemical等国际期刊上发表SCI论文6篇。|许瑞，副教授，博士，E-mail：dentistxr@126.com|邹多宏，口腔临床医学博士，博士后，上海交通大学医学院附属第九人民医院研究员、教授、博士生导师，口腔外科行政副主任。美国密歇根大学高级访问学者，英国英格兰皇家外科学院Fellowship。中华口腔医学会牙及牙槽外科专业委员会副主任委员，上海市口腔医学会牙及牙槽外科专业委员会主任委员，中华口腔医学会口腔种植专业委员会委员，上海市口腔医学会口腔种植专业委员会常务委员。入选上海市卫生健康学科带头人、上海市杰出青年医学人才及安徽省杰青，并以第一完成人获得上海市青年科技杰出贡献奖、教育部科学技术进步奖二等奖及第六届转化医学奖创新奖等7个奖项。|长期致力于牙槽骨修复及口腔种植基础与临床转化研究。主持包括5项国家自然科学基金在内的20余项课题，入选5项省/局级人才计划。近年来以通讯作者（含共同通讯作者）在Nature Biomedical Engineering、National Science Review、Science Advances、Advanced Materials、Cell Death and Differentiation、Biomaterials、Stem Cells及Journal of Dental Research等期刊发表SCI论文35篇，其中15篇IF>10；主编专著3部，主译专著1部，获授权专利152件，完成了6项科技成果转化，转化经费2 575万元，获批3张三类医疗器械注册证。基于“以稳定为核心”的牙槽骨修复治疗理念，创建了单纯人工骨粉修复牙槽骨重度缺损新技术；研发了国际首款老年口腔种植体及专用手术器械。新技术及医疗产品在全国2 000多家医疗机构推广应用，助推了口腔种植医疗器械国产化进程。
基金资助:
国家自然科学基金(92368111);上海市卫生健康委员会卫生健康学科带头人培养计划(2022XD038);上海交通大学医学院生物材料与再生医学研究院联合攻关重点项目(2022LHA04);上海交通大学医学院附属第九人民医院原创探索项目(JYYC007)

Design strategy of hydrogel wound dressings based on oral special environment

Xu Rui¹(), Pan Zhao², Zou Duohong³()

^1.College & Hospital of Stomatology, Anhui Medical University, Key Laboratory of Oral Diseases Research of Anhui Province, Hefei 230032, China
^2.Hangzhou Institute of Medicine, Chinese Academy of Sciences, Hangzhou 310022, China
^3.Dept. of Oral Surgery, Shanghai Ninth People’s Hospital, Shanghai JiaoTong University School of Medicine; College of Stomatology, Shanghai JiaoTong University; National Center for Stomatology; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology, Shanghai 200011, China

Received:2024-07-14 Revised:2024-08-03 Online:2024-12-01 Published:2024-11-29
Contact: Zou Duohong E-mail:dentistxr@126.com;zouduohongyy@163.com
Supported by:
National Natural Science Foundation of China(92368111);Training Plan for Health Discipline Leaders of Shanghai Municipal Health Commission(2022XD038);Biomaterials and Regenerative Medicine Institute Cooperative Research Project, Shanghai JiaoTong University School of Medicine(2022LHA04);Original Exploration Project of Shanghai Ninth People’s Hospital, Shanghai JiaoTong University School of Medicine(JYYC007)

摘要/Abstract

摘要：

外伤、手术、疾病以及化学刺激等造成的口腔内创伤为患者带来疼痛并增加感染风险。有效的创面保护及修复对提高患者生活质量和维护口腔健康至关重要。敷贴材料通过阻隔创面与口腔环境，为创面提供理想的愈合条件。然而在口腔高度湿润且微生物富集的动态环境下，伤口敷贴如何保持性能稳定仍面临巨大挑战。水凝胶因其良好的生物安全性以及性能多样性展现出广阔的应用前景，成为解决口腔创面保护及修复难题的研究热点。本文探讨水凝胶敷贴克服口腔特殊环境实现持久黏附及功能发挥的设计策略，以期为理想的口腔创面屏障材料设计提供新思路。

关键词: 口腔创面, 水凝胶敷贴, 湿态粘接, 机械性能, 药物控释

Abstract:

Oral wounds caused by injuries, surgeries, diseases, and chemical irritations bring pain to the patient and increase the risk of infection. Effective wound protection and repair are crucial for improving patients’ quality of life and maintaining oral health. Wound dressings provide ideal healing conditions by isolating the wound from the oral environment. However, in the highly moist, microbiologically rich environment of the oral cavity, maintaining the stability of wound dressings remains a considerable challenge. Hydrogels show promising prospects for oral applications and are gradually becoming a research hotspot for addressing the challenges of oral wound protection and repair due to their excellent biocompatibility and versatile performance. In this paper, the current design strategies of hydrogel wound dressings that overcome the unique oral environment, achieve sustained adhesion and fulfill their functions are reviewed to provide new insights for the design of ideal oral wound barrier materials.

Key words: oral wounds, hydrogel dressing, wet adhesion, mechanical properties, controlled drug release systems

中图分类号:

R783.1

许瑞, 潘钊, 邹多宏. 基于口腔特殊环境的水凝胶创面敷贴设计策略[J]. 华西口腔医学杂志, 2024, 42(6): 689-698.

Xu Rui, Pan Zhao, Zou Duohong. Design strategy of hydrogel wound dressings based on oral special environment[J]. West China Journal of Stomatology, 2024, 42(6): 689-698.

图/表 1

参考文献 78

1	Politis C, Schoenaers J, Jacobs R, et al. Wound healing problems in the mouth[J]. Front Physiol, 2016, 7: 507.
2	Ko KI, Sculean A, Graves DT. Diabetic wound healing in soft and hard oral tissues[J]. Transl Res, 2021, 236: 72-86.
3	Ding Y, Zhu Z, Zhang X, et al. Novel functional dres-sing materials for intraoral wound care[J]. Adv Healthc Mater, 2024. doi: 10.1002/adhm.202400912 .
4	Dawes C, Wong DTW. Role of saliva and salivary diagnostics in the advancement of oral health[J]. J Dent Res, 2019, 98(2): 133-141.
5	Hatcher DC. Anatomy of the mandible, temporomandi-bular joint, and dentition[J]. Neuroimaging Clin N Am, 2022, 32(4): 749-761.
6	Baker JL, Mark Welch JL, Kauffman KM, et al. The oral microbiome: diversity, biogeography and human health[J]. Nat Rev Microbiol, 2024, 22(2): 89-104.
7	Jia B, Zhang B, Li J, et al. Emerging polymeric mate-rials for treatment of oral diseases: design strategy towards a unique oral environment[J]. Chem Soc Rev, 2024, 53(7): 3273-3301.
8	Huang M, Huang Y, Liu H, et al. Hydrogels for the treatment of oral and maxillofacial diseases: current resear-ch, challenges, and future directions[J]. Biomater Sci, 2022, 10(22): 6413-6446.
9	Buwalda SJ, Boere KW, Dijkstra PJ, et al. Hydrogels in a historical perspective: from simple networks to smart materials[J]. J Control Release, 2014, 190: 254-273.
10	Li S, Dong S, Xu W, et al. Antibacterial hydrogels[J]. Adv Sci, 2018, 5: 1700527.
11	Yang J, Zhang YS, Yue K, et al. Cell-laden hydrogels for osteochondral and cartilage tissue engineering[J]. Acta Biomater, 2017, 57: 1-25.
12	Roorda WE, Boddé HE, De Boer AG, et al. Synthetic hydrogels as drug delivery systems[J]. Pharm Weekbl Sci, 1986, 8(3): 165-189.
13	Anseth KS, Bowman CN, Brannon-Peppas L. Mechanical properties of hydrogels and their experimental determination[J]. Biomaterials, 1996, 17(17): 1647-1657.
14	Francis L, Greco KV, Boccaccini AR, et al. Development of a novel hybrid bioactive hydrogel for future cli-nical applications[J]. J Biomater Appl, 2018, 33(3): 447-465.
15	Catoira MC, Fusaro L, Di Francesco D, et al. Overview of natural hydrogels for regenerative medicine applications[J]. J Mater Sci Mater Med, 2019, 30(10): 115.
16	Spang MT, Christman KL. Extracellular matrix hydrogel therapies: in vivo applications and development[J]. Acta Biomater, 2018, 68: 1-14.
17	Bao Z, Xian C, Yuan Q, et al. Natural polymer-based hydrogels with enhanced mechanical performances: preparation, structure, and property[J]. Adv Healthc Mater, 2019, 8(17): e1900670.
18	Kolawole OM, Lau WM, Khutoryanskiy VV. Methacrylated chitosan as a polymer with enhanced mucoadhesive properties for transmucosal drug delivery[J]. Int J Pharm, 2018, 550(1/2): 123-129.
19	Zhu Z, Guan Z, Jia S, et al. Au@Pt nanoparticle encapsulated target-responsive hydrogel with volumetric bar-chart chip readout for quantitative point-of-care testing[J]. Angew Chem Int Ed Engl, 2014, 53(46): 12503-12507.
20	Dimatteo R, Darling NJ, Segura T. In situ forming injec-table hydrogels for drug delivery and wound repair[J]. Adv Drug Deliv Rev, 2018, 127: 167-184.
21	Bernkop-Schnürch A. Thiomers: a new generation of mucoadhesive polymers[J]. Adv Drug Deliv Rev, 2005, 57(11): 1569-1582.
22	Dong Y, Pang H, Yang HB, et al. Carbon-based dots co-doped with nitrogen and sulfur for high quantum yield and excitation-independent emission[J]. Angew Chem Int Ed Engl, 2013, 52(30): 7800-7804.
23	Chatterjee B, Amalina N, Sengupta P, et al. Mucoadhesive polymers and their mode of action: a recent update[J]. J Appl Pharm Sci, 2017, 7: 195-203.
24	Jelkmann M, Bonengel S, Menzel C, et al. New perspectives of starch: synthesis and in vitro assessment of no-vel thiolated mucoadhesive derivatives[J]. Int J Pharm, 2018, 546(1/2): 70-77.
25	Laffleur F. Mucoadhesive polymers for buccal drug delivery[J]. Drug Dev Ind Pharm, 2014, 40(5): 591-598.
26	Yang J, Bai R, Chen B, et al. Hydrogel adhesion: a supramolecular synergy of chemistry, topology, and mechanics[J]. Adv Funct Mater, 2020, 30(2): 1901693.
27	Wuttig M, Deringer VL, Gonze X, et al. Incipient me-tals: functional materials with a unique bonding mechanism[J]. Adv Mater, 2018, 30(51): e1803777.
28	Ma S, Wu Y, Zhou F. Bioinspired synthetic wet adhesives: from permanent bonding to reversible regulation[J]. Curr Opin Colloid Interface Sci, 2020, 47: 84-98.
29	Morales JO, Brayden DJ. Buccal delivery of small molecules and biologics: of mucoadhesive polymers, films, and nanoparticles[J]. Curr Opin Pharmacol, 2017, 36: 22-28.
30	Salamat-Miller N, Chittchang M, Johnston TP. The use of mucoadhesive polymers in buccal drug delivery[J]. Adv Drug Deliv Rev, 2005, 57(11): 1666-1691.
31	Steck J, Kim J, Yang J, et al. Topological adhesion. I. Rapid and strong topohesives[J]. Extreme Mech Lett, 2020, 39: 100803.
32	Daristotle JL, Zaki ST, Lau LW, et al. Pressure-sensitive tissue adhesion and biodegradation of viscoelastic po-lymer blends[J]. ACS Appl Mater Interfaces, 2020, 12(14): 16050-16057.
33	Sennakesavan G, Mostakhdemin M, Dkhar LK, et al. Acrylic acid/acrylamide based hydrogels and its pro-perties—A review[J]. Polym Degrad Stab, 2020, 180: 109308.
34	Macdougall LJ, Anseth K. Bioerodible hydrogels based on photopolymerized poly(ethylene glycol)-co-poly(α- hydroxy acid) diacrylate macromers[J]. Macromolecules, 2020, 53(7): 2295-2298.
35	Zhang X, Li Z, Yang P, et al. Polyphenol scaffolds in tissue engineering[J]. Mater Horiz, 2021, 8(1): 145-167.
36	Hong S, Pirovich D, Kilcoyne A, et al. Supramolecular metallo-bioadhesive for minimally invasive use[J]. Adv Mater, 2016, 28(39): 8675-8680.
37	Lee HA, Park E, Lee H. Polydopamine and its derivati-ve surface chemistry in material science: a focused review for studies at KAIST[J]. Adv Mater, 2020, 32(35): e1907505.
38	Yang J, Saggiomo V, Velders AH, et al. Reaction pa-thways in catechol/primary amine mixtures: a window on crosslinking chemistry[J]. PLoS One, 2016, 11(12): e0166490.
39	Hu H, Xu FJ. Rational design and latest advances of polysaccharide-based hydrogels for wound healing[J]. Biomater Sci, 2020, 8(8): 2084-2101.
40	Berradi A, Aziz F, Achaby ME, et al. A comprehensive review of polysaccharide-based hydrogels as promising biomaterials[J]. Polymers (Basel), 2023, 15(13): 2908.
41	Hu S, Pei X, Duan L, et al. A mussel-inspired film for adhesion to wet buccal tissue and efficient buccal drug delivery[J]. Nat Commun, 2021, 12(1): 1689.
42	Boda SK, Fischer NG, Ye Z, et al. Dual oral tissue adhesive nanofiber membranes for pH-responsive delivery of antimicrobial peptides[J]. Biomacromolecules, 2020, 21(12): 4945-4961.
43	Liu H, Liu C, Shao D, et al. A tough Janus hydrogel patch with strong wet adhesion and self-debonding for oral ulcer treatment[J]. Chem Mater, 2024, 36(10): 4976-4989.
44	Cui C, Mei L, Wang D, et al. A self-stabilized and water-responsive deliverable coenzyme-based polymer binary elastomer adhesive patch for treating oral ulcer[J]. Nat Commun, 2023, 14(1): 7707.
45	Ryu JH, Choi JS, Park E, et al. Chitosan oral patches inspired by mussel adhesion[J]. J Control Release, 2020, 317: 57-66.
46	Xing J, Ding Y, Zheng X, et al. Barnacle-Inspired ro-bust and aesthetic Janus patch with instinctive wet adhesive for oral ulcer treatment[J]. Chem Eng J, 2022, 444: 136580.
47	Bao BK, Zeng QM, Li K, et al. Rapid fabrication of phy-sically robust hydrogels[J]. Nat Mater, 2023, 22: 1253-1260.
48	Zaragoza J, Fukuoka S, Kraus M, et al. Exploring the role of nanoparticles in enhancing mechanical properties of hydrogel nanocomposites[J]. Nanomaterials, 2018, 8(11): 882.
49	Montazerian H, Davoodi E, Baidya A, et al. Bio-macromolecular design roadmap towards tough bioadhesives[J]. Chem Soc Rev, 2022, 51(21): 9127-9173.
50	Zhang X, Zhang R, Wu S, et al. Physically and chemically dual-crosslinked hydrogels with superior mechanical properties and self-healing behavior[J]. New J Chem, 2020, 44(23): 9903-9911.
51	Zhu J, Li Y, Xie W, et al. Low-swelling adhesive hydrogel with rapid hemostasis and potent anti-inflammatory capability for full-thickness oral mucosal defect repair[J]. ACS Appl Mater Interfaces, 2022, 14(48): 53575-53592.
52	Yuan Y, Shen S, Fan D. A physicochemical double cross-linked multifunctional hydrogel for dynamic burn wound healing: shape adaptability, injectable self-hea-ling property and enhanced adhesion[J]. Biomaterials, 2021, 276: 120838.
53	Wu J, Pan Z, Zhao ZY, et al. Anti-swelling, robust, and adhesive extracellular matrix-mimicking hydrogel used as intraoral dressing[J]. Adv Mater, 2022, 34(20): e22-00115.
54	Ankareddi I, Brazel CS. Synthesis and characterization of grafted thermosensitive hydrogels for heating activa-ted controlled release[J]. Int J Pharm, 2007, 36(2): 241-247.
55	Zhang Y, Zhu W, Wang B, et al. A novel microgel and associated post-fabrication encapsulation technique of proteins[J]. J Control Release, 2005, 105(3): 260-268.
56	Huang D, Sun M, Bu Y, et al. Microcapsule-embedded hydrogel patches for ultrasound responsive and enhan-ced transdermal delivery of diclofenac sodium[J]. J Mater Chem B, 2019, 7(14): 2330-2337.
57	Kass LE, Nguyen J. Nanocarrier-hydrogel composite delivery systems for precision drug release[J]. Wiley Interdiscip Rev Nanomed Nanobiotechnol, 2022, 14(2): e1756.
58	Babaladimath G, Badalamoole V. Magnetic nanopar-ticles embedded in pectin-based hydrogel for the sustained release of diclofenac sodium[J]. Polym Int, 2018, 67: 983-992.
59	Chan AW, Neufeld RJ. Tuneable semi-synthetic network alginate for absorptive encapsulation and controlled release of protein therapeutics[J]. Biomaterials, 2010, 31(34): 9040-9047.
60	Zhang L, Ma Y, Zhao C, et al. Synthesis of pH-responsive hydrogel thin films grafted on PCL substrates for protein delivery[J]. J Mater Chem B, 2015, 3(39): 7673-7681.
61	Shohraty F, Najafi Moghadam P, Fareghi A, et al. Synthesis and characterization of new pH-sensitive hydrogels based on poly(glycidyl methacrylate-co-maleic anhydride)[J]. Adv Polym Technol, 2018, 37(1): 120-125.
62	Mahkam M, Poorgholy N, Vakhshouri L. Synthesis and characterization of novel pH-sensitive hydrogels contai-ning ibuprofen pendents for colon-specific drug delivery[J]. Macromol Res, 2009, 17(9): 709-713.
63	Zhang Y, Ding J, Sun D, et al. Thermogel-mediated sustained drug delivery for in situ malignancy chemotherapy[J]. Mater Sci Eng C Mater Biol Appl, 2015, 49: 262-268.
64	Bastiancich C, Danhier P, Préat V, et al. Anticancer drug-loaded hydrogels as drug delivery systems for the local treatment of glioblastoma[J]. J Control Release, 2016, 243: 29-42.
65	Burakowska E, Zimmerman SC, Haag R. Photoresponsive crosslinked hyperbranched polyglycerols as smart nanocarriers for guest binding and controlled release[J]. Small, 2009, 5(19): 2199-2204.
66	Rai P, Mallidi S, Zheng X, et al. Development and ap-plications of photo-triggered theranostic agents[J]. Adv Drug Deliv Rev, 2010, 62(11): 1094-124.
67	Mahinroosta M, Jomeh Farsangi Z, Allahverdi A, et al. Hydrogels as intelligent materials: a brief review of synthesis, properties and applications[J]. Mater Today Chem, 2018, 8: 42-55.
68	Kalafatovic D, Nobis M, Son J, et al. MMP-9 triggered self-assembly of doxorubicin nanofiber depots halts tumor growth[J]. Biomaterials, 2016, 98: 192-202.
69	白靖琨, 盛成乐, 张宇, 等. 酶响应型肽水凝胶及应用研究进展[J]. 生物化学与生物物理进展, 2016, 43(11): 1048-1060.
	Bai JK, Sheng CL, Zhang Y, et al. Progress in enzyme responsive peptide hydrogel and its applications[J]. Prog Biochem Biophy, 2016, 43(11): 1048-1060.
70	Chen D, Zhang G, Li R, et al. Biodegradable, hydrogen peroxide, and glutathione dual responsive nanoparticles for potential programmable paclitaxel release[J]. J Am Chem Soc, 2018, 140(24): 7373-7376.
71	Moriyama K, Minamihata K, Wakabayashi R, et al. Enzymatic preparation of a redox-responsive hydrogel for encapsulating and releasing living cells[J]. Chem Commun (Camb), 2014, 50(44): 5895-5898.
72	Qi W, Dong N, Wu L, et al. Promoting oral mucosal wound healing using a DCS-RuB2A2 hydrogel based on a photoreactive antibacterial and sustained release of BMSCs[J]. Bioact Mater, 2022, 23: 53-68.
73	Tan X, Liu S, Hu X, et al. Near-infrared-enhanced dual enzyme-mimicking Ag-TiO₂-x@alginate microspheres with antibactericidal and oxygeneration abilities to treat periodontitis[J]. ACS Appl Mater Interfaces, 2023, 15(1): 391-406.
74	Qu X, Guo X, Zhu T, et al. Microneedle patches contai-ning mesoporous polydopamine nanoparticles loaded wi-th triamcinolone acetonide for the treatment of oral mucositis[J]. Front Bioeng Biotechnol, 2023, 11: 1203709.
75	Zhang Z, Zhang Q, Gao S, et al. Antibacterial, anti-inflammatory and wet-adhesive poly(ionic liquid)-based oral patch for the treatment of oral ulcers with bacterial infection[J]. Acta Biomater, 2023, 166: 254-265.
76	Wen X, Xi K, Tang Y, et al. Immunized microspheres engineered hydrogel membrane for reprogramming ma-crophage and mucosal repair[J]. Small, 2023, 19(15): e2207030.
77	Xu S, Hu B, Dong T, et al. Alleviate periodontitis and its comorbidity hypertension using a nanoparticle-embedded functional hydrogel system[J]. Adv Healthc Mater, 2023, 12(20): e2203337.
78	Bao X, Zhao J, Sun J, et al. Polydopamine nanoparticles as efficient scavengers for reactive oxygen species in periodontal disease[J]. ACS Nano, 2018, 12(9): 8882-8892.

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基于口腔特殊环境的水凝胶创面敷贴设计策略

Design strategy of hydrogel wound dressings based on oral special environment

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