口腔黏膜黏附材料的研究进展

doi:10.7518/hxkq.2023.01.001

华西口腔医学杂志 ›› 2023, Vol. 41 ›› Issue (1): 1-10.doi: 10.7518/hxkq.2023.01.001

• 专家论坛 • 下一篇

口腔黏膜黏附材料的研究进展

赵行()

口腔疾病研究国家重点实验室国家口腔疾病临床医学研究中心四川大学华西口腔医学院口腔基础医学系，成都 610041

收稿日期:2022-09-06 修回日期:2022-12-28 出版日期:2023-02-01 发布日期:2023-02-21
通讯作者: 赵行 E-mail:zhaohangahy@scu.edu.cn
作者简介:赵行，研究员，博士生导师，四川大学华西口腔医（学）院口腔基础医学系主任及口腔材料学教研室主任，任四川省口腔医学会口腔生物学专业委员会主任委员等。作为负责人主持国家自然科学基金（包括优秀青年基金、面上项目）、中国科学技术协会青年人才托举工程、四川省科技厅重点项目等10余项，主要研究方向为“口腔黏膜局部药物制剂与靶向递送系统的应用基础研究”，在国内通过交叉学科展开具有自主知识产权的创新性研究，成果以第一/通讯作者发表在Nat Commun、Adv Mater、Mater Today、Adv Funct Mater、ACS NANO、Biomaterials、JDR等期刊上，共计32篇；申请国家发明专利13项，转化1项。入选教育部重要人才计划青年项目和第十四批四川省卫生健康委员会学术带头人才，获2021年四川省自然科学一等奖。
基金资助:
国家自然科学基金(81922020);四川省科技厅项目(2021-YJ-2021)

Progress of research on oral mucosal adhesive agents

Zhao Hang.()

State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Preclinical Stomatology, West China School of Stomatology, Sichuan University, Chengdu 610041, China

Received:2022-09-06 Revised:2022-12-28 Online:2023-02-01 Published:2023-02-21
Contact: Zhao Hang. E-mail:zhaohangahy@scu.edu.cn
Supported by:
The National Natural Science Foundations of China(81922020);The Sichuan Provincial Department of Science and Technology(2021-YJ-2021)

摘要/Abstract

摘要：

基于口腔黏膜结构的独特性和给药的方便性，局部药物递送在口腔黏膜疾病的治疗中得到广泛应用。但由于口腔是一个有开放、湿润及运动的特殊微环境，口腔黏膜给药面临着巨大挑战。针对这一困境，近年来黏附材料得以深入研究，以期延长药物局部停留时间，从而达到药物缓释和提高生物利用度的目的，具有广泛的应用前景，本文将针对口腔黏膜黏附材料的特点和现状简要总结。

关键词: 口腔黏膜, 局部给药, 黏附

Abstract:

Oral mucosal administration is extensively used to treat systemic diseases and oral mucosal diseases owing to unique oral mucosal structure and convenient administration. However, the special microenvironment of the oral cavity being open, moving, and humid causes oral mucosal drug delivery to face great challenges. To address this dilemma, local adhesive agents have been widely studied for sustained drug delivery and improved bioavailability, showing broad prospects. Recently, the author has performed studies on oral mucosal adhesive agents. In this paper, the progress of research on oral mucosal adhesive materials is reviewed.

Key words: oral mucosa, local administration, adhesion

中图分类号:

R 78

赵行. 口腔黏膜黏附材料的研究进展[J]. 华西口腔医学杂志, 2023, 41(1): 1-10.

Zhao Hang.. Progress of research on oral mucosal adhesive agents[J]. West China Journal of Stomatology, 2023, 41(1): 1-10.

图/表 3

参考文献 88

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口腔黏膜黏附材料的研究进展

Progress of research on oral mucosal adhesive agents

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