口腔癌相关生存质量量表的系统性回顾研究

doi:10.7518/hxkq.2018.04.012

摘要/Abstract

摘要：

目的口腔癌相关生存质量研究现在愈来愈成为临床中的焦点问题,本研究旨在系统回顾国内外关于口腔癌患者生存质量评价的研究现况,探讨研究中存在的问题和今后研究的方向,为解决该问题提供参考。方法通过相关关键词对Pubmed、Wiley InterScience、Science Direct、中国知网、万方期刊数据库分别进行检索,其次对2000—2017年的相关目标文献进行筛选,统计文献中使用的口腔癌相关生存质量量表频次,并对相关量表作简单介绍。结果从目标文献中共筛选出218篇英文目标文献,55篇中文目标文献,获得英文量表24种,中文量表12种,其中针对口腔癌患者生存质量评估使用最多的量表有华盛顿大学生存质量评估问卷（UW-QOL）、欧洲癌症研究与治疗组织生存质量量表的核心量表/头颈癌专用量表（EORTC QLQ-C30/H&N35）、口腔健康影响程度量表（OHIP）、癌症治疗功能评价系统—头颈问卷（FACT-H&N）、36条目简明健康状况调查问卷（SF-36）。结论近年来口腔癌相关生存质量的研究如火如荼,研究地理分布区域广泛,但国内自主开发研制量表工作仍然不足;UW-QOL、EORTC QLQ-C30/H&N35、FACT-H&N可以作为今后口腔癌患者生存质量评价的首选量表,此外,还可根据特定的研究目标选择特异性疾病相关功能量表。

关键词: 口腔癌, 生存质量, 量表

Abstract:

Objective The quality of life (QOL) related to oral cancer has recently become a focus of clinical studies. This study aims to systematically review the current research situation of QOL of local and foreign oral cancer patients and explore the existing related problems and future research directions to provide references and solutions. Methods Through relevant key words, PubMed, Wiley InterScience, Science Direct, CNKI, and Wanfang databases were first searched. The related target literature from 2000 to 2017 were screened. Finally, the frequency of oral cancer related to QOL scale used in literature was calculated, and the related scales were briefly introduced. Results From the target literature, 218 English target literature, 55 Chinese target literature, 24 English scales, and 12 Chinese scales were selected. The most widely used scales for assessing the QOL of patients with oral cancer were as follows: University of Washington Quality of Life Questionnaire (UW-QOL), European Organization for the Research and Treatment of Cancer Quality of Life Questionnaire Core 30/Head and Neck 35 (EORTC QLQ-C30/H&N35), 36-Item Short-Form Health Survey (SF-36), Functional Assessment of Cancer Therapy-Head and Neck (FACT-H&N), and Oral Health Impact Profile (OHIP). Conclusion The QOL related to oral cancer was well underway, and the study of geographical distribution was widespread. However, the work on self-developed scale remains inadequate. UW-QOL, EORTC QLQ-C30/H&N35, and FACT-H&N can be utilized as the preferred scales for evaluating the QOL of oral cancer patients. A specific disease-related function scale can also be selected according to specific research objectives.

Key words: oral cancer, quality of life, scale

中图分类号:

R739.8

秦帅华, 李新明, 李文鹿. 口腔癌相关生存质量量表的系统性回顾研究[J]. 华西口腔医学杂志, 2018, 36(4): 410-420.

Shuaihua Qin, Xinming Li, Wenlu Li. Systematic retrospective study of oral cancer-related quality of life scale[J]. West China Journal of Stomatology, 2018, 36(4): 410-420.

图/表 3

表 1

英文文献中各量表使用频次

量表	使用	量表	使用
量表	频数	量表	频数
华盛顿大学生存质量评估问卷（University of Washington	83	范德比尔特头颈部症状调查表（Vanderbilt Head and Neck	2
Quality of Life Questionnaire,UW-QOL）^a		Symptom Survey,VHNSS）^a
欧洲癌症研究与治疗组织生存质量量表的核心量表/头颈癌	61	旧金山加利福尼亚大学口腔癌疼痛问卷（University of Cali-	5
专用量表（European Organisation for the Research and Treat-		fornia San Francisco Oral Cancer Pain Questionnaire,UCSF-
ment of Cancer Quality of Life Questionnaire Core 30/Head and		OCPQ）^c
Neck 35,EORTC QLQ-C30/H&N35）^a
口腔健康影响程度量表（Oral Health Impact Profile,OHIP）^b	24	世界卫生组织生存质量测定量表（The World Health Organi-	1
		zation Quality of Life instrument-100,WHO QOL-100）^b
癌症治疗功能评价系统—头颈问卷（Functional Assessment	20	世界卫生组织生存质量测定简表（The World Health Organiza-	1
of Cancer Therapy-Head and Neck,FACT-H&N）^a		tion Quality of Life Scale Brief Version,WHO QOL-BREF）^b
36条目简明健康状况调查问卷（36-Item Short-Form Health	14	语音障碍指数（Speech Handicap Index,SHI）^c	9
Survey,SF-36）^b
12条目简明健康状况调查问卷（12-Item Short-Form Health	4	伦敦语音评价量表（London Speech Evaluation scale,LSES）^c	2
Survey,SF-12）^b,是SF-36的简化版
欧洲五维健康量表（EuroQol Five Dimensions Questionnaire,	6	悉尼吞咽功能问卷（Sydney Swallow Questionnaire,SSQ）^c	1
EQ-5D）^b
头颈癌症目录（Head and Neck Cancer Inventory,HNCI）^a	8	吞咽障碍特异性生存质量量表（Swallow Quality-of-Life	3
		Questionnaire,SWAL-QOL）^c
头颈肿瘤行为状态量表（Performance Status Scale for Head	7	安德森吞咽困难量表（MD Anderson Dysphagia Inventory,	5
and Neck Cancer,PSS-HN）^a		MDAD）^c
利物浦口腔健康问卷（Liverpool Oral Rehabilitation Ques-	3	吞咽困难结局及严重量表（Dysphagia Outcome and Severity	2
tionnaire,LORQ）^a		Scale,DOSS）^c
密歇根大学头颈癌生存质量量表（University of Michican	6	口干症相关生存质量量表（Xerostomia-Related Quality-of-	1
Head and Neck Quality of Life,U of M-HNQOL）^a		Life Scale,XeQOLS）^c
头颈癌口腔黏膜炎每周问卷（Oral Mucositis Weekly Ques-	2	封闭功能量表（Obturator Functioning Scale,OFS）^c	9
tionnaire-Head and Neck,OMWQ-HN）^c

表 1

表 2

表 3

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量表	使用频数	量表	使用频数
UW-QOL^a	34	头颈癌生存质量量表中国版（Quality of Life Instruments	3
		for Cancer Patients-Head and Neck cancer,QLICP-HN）^a
EORTC QLQ-C30/H&N35^a	13	WHO QOL-100^b	1
SF-36^b	8	WHO QOL-BREF^b
FACT-H&N^a	8	PSS-HN^a	1
49条目OHIP（OHIP-49）^a	2	口腔健康评估表（Oral Health Assessment Tool,OHAT）^a	1
14条目OHIP（OHIP-14）^a,是OHIP-49的简化版	3	饮食评估工具（Eating Assessment Tool,EAT-10）^c	2