关键词: 牙周炎, 伴放线放线杆菌, 牙龈卟啉单胞菌, 免疫功能低下, 动物模型

Abstract:

Objective　The aim of this studywas to investigate effects of immunodeficiency on the periodontal infection char- acters of the specific pathogens of juvenile periodontitis.Methods　A total of 36 immunodeficient guinea pigs produced by twice whole-body irradiation with60Co were divided randomly into four groups, in whichActinobacillus actinomycetemcomitans,Porphy- romonas gingivalis, andA.actinomycetemcomitanswithP.gingivaliswere inoculated into the gingival sulcus of two mandibular inci- sors respectively. The pigs in the control group did not receive any inoculation. At 2, 3 and 6 weeks after inoculation, three animals in each group were sacrificed successively. Clinical and histological examinationswere used to examine the changes in the periodontal tissues. The other36 normal guinea pigswere divided into fourgroups and treated in a similarway described above.Results　Signif- icant periodontal damages were noted in immunodeficient pigs inoculated withA.actinomycetemcomitans,P.gingivalisorA.acti- nomycetemcomitansandP.gingivalisin 2 and 3 weeks after bacterial inoculation. The damages were more severe than in the normal groups. The immunodeficient groups demonstrated larger numbers of osteoclasts than the normal groups (P<0.05).Conclusion　 The loss of periodontal tissue in immunodeficient hosts is much serious than those with normal defence system, after they are infected withA.actinomycetemcomitansandP.gingivalis. Abnormal defence system in hostsmay play an important role in onset and develop- ment of juvenile periodontitis.

Key words: juvenile periodontitis, Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis, immunodeficien- cy, animal model