华西口腔医学杂志

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口腔扁平苔藓患者白色念珠菌分离株的颊细胞粘附力研究

曾 昕1,陈谦明1,聂敏海2,李秉琦1   

  1. 1.四川大学华西口腔医院 口腔黏膜病科,四川 成都610041; 2.泸州医学院附属口腔医院 口腔内科,四川 泸州646000
  • 收稿日期:2005-12-25 修回日期:2005-12-25 出版日期:2005-12-20 发布日期:2005-12-20
  • 通讯作者: 陈谦明,Tel:028-85503480
  • 作者简介:曾 昕(1970-),女,重庆人,副教授,博士
  • 基金资助:
    国家自然科学基金资助项目(30300387);“十五”国家科技攻关计划资助项目(2004BA720A28)

Adhesion to Buccal Epithelial Cells ofCandida albicansIsolates from Oral Lichen Planus

ZENG Xin1,CHEN Qian-ming1,NIEMin-hai2,LIBing-qi1   

  1. 1.Dept.ofOral Medicine,West China College ofStomatology,Sichuan University,Cheng- du610041,China;2.Dept.ofOral Medicine,School ofStomatology,Luzhou Medical College,Luzhou646000,Chin
  • Received:2005-12-25 Revised:2005-12-25 Online:2005-12-20 Published:2005-12-20

摘要: 的 研究健康人和口腔扁平苔藓患者口腔白色念珠菌分离株的颊细胞粘附力。方法 应用颊细胞粘 附实验法,比较来自于健康人(26株)、糜烂型口腔扁平苔藓患者(62株)以及非糜烂型口腔扁平苔藓患者(24株)共 112株白色念珠菌对人颊细胞粘附力的大小。结果 糜烂型口腔扁平苔藓患者组的白色念珠菌分离株的平均粘附 数较健康对照组高(P<0·05),说明糜烂型口腔扁平苔藓患者组白色念珠菌分离株的颊细胞粘附力高于健康对照 组。结论 糜烂型口腔扁平苔藓患者组的白色念珠菌分离株与健康对照组相比,具有不同的毒性特征,白色念珠 菌与糜烂型口腔扁平苔藓发生发展可能相关。

关键词: 白色念珠菌, 粘附力, 口腔扁平苔藓

Abstract: Objective To investigate the adhesion to buccal epithelial cells ofCandida albicansisolates from erosive oral li- chen planus(OLP) and nonerosive OLP, and its role in the development of OLP.Methods A total of 112 isolates, comprising healthy control (26),erosive OLP (62) and nonerosive OLP (24), were screened for the adhesion by using buccal epithelial cell (BEC) assay.Results The adhesion to buccal epithelial cells of the isolates from erosive OLP group was stronger than that of those from healthy control.Conclusion Candida albicans, some isolates with a special virulence attribute may contribute to the occurrence and progression of erosive OLP.

Key words: Candida albicans, adhesion to buccal epithelial cells, oral lichen planus