华西口腔医学杂志

• 临床研究 • 上一篇    下一篇

定量光导荧光技术评价含氟牙膏抑制早期龋损效果的临床研究

冯岩1,2, 尹伟2, 胡德渝2, Yunpo Zhang3, Iain A. Pretty4, Roger P. Ellwood4   

  1. 福建医科大学附属口腔医院预防科;四川大学华西口腔医学院口腔预防医学教研室;DentalHealthUnit,ManchesterDentalSchool,ManchesterM156SH,UK;
  • 收稿日期:2008-12-25 修回日期:2008-12-25 出版日期:2008-12-20 发布日期:2008-12-20
  • 通讯作者: 胡德渝,Tel:028-85501457
  • 作者简介:冯岩(1976-),女,河北人,主治医师,博士

Detection and prevention of early caries after fluoride dentifrice application using quantitative light-induced fluorescence in vivo

FENG Yan1,2, YIN Wei2, HU De-yu2, Yunpo Zhang3,Iain A. Pretty4, Roger P. Ellwood4   

  1. 1.福建医科大学附属口腔医院预防科, 福建福州350002;2.四川大学华西口腔医学院口腔预防医学教研室, 四川成都610041;3.Colgate-Palmolive Company, NY 08854, USA; 4.Dental Health Unit, Manchester Dental School, Manchester M156SH, UK
  • Received:2008-12-25 Revised:2008-12-25 Online:2008-12-20 Published:2008-12-20
  • Contact: HU De-yu,Tel:028-85501457

摘要:

目的评价定量光导荧光技术(QLF)用于纵向监测光滑面早期龋损矿物质含量变化的能力及用于评价不同氟化物抑制早期龋损效果差异的可能性。方法选取305名11~14岁上颌前牙有早期光滑面龋的中小学生,随机分为NaF组、MFP组和不含氟组,分别采用含NaF的牙膏、含Na2PO3F的牙膏(氟浓度均为1 450 mg/L)和不含氟的牙膏刷牙。拍摄受检者上颌前牙光滑面早期龋损基线、刷牙后3个月和6个月时的QLF照片并保存。使用软件QLF2.00g对病损进行分析,界定病损范围,得出每次检查的△F(荧光损失)、Area(病损面积)和△Q(总荧光损失量)。结果296名(97.05%)受检者完成了整个研究。QLF检查结果显示,3个月时,296名受检者上颌前牙光滑面早期龋损均出现不同程度的好转,3组光滑面早期龋损Area、△F和lg△Q的变化均无统计学差异(P>0.05);6个月时,296名受检者上颌前牙光滑面早期龋损均较基线时出现明显的好转,NaF组、MFP组光滑面早期龋损Area、△F和lg△Q的变化有统计学差异(P<0.05),而NaF组与MFP组之间无统计学差异(P>0.05)。结论QLF作为一种定量诊断方法,能够用于纵向病变跟踪监测和评价不同龋病干预措施效果。

关键词: 定量光导荧光技术, 含氟牙膏, 早期龋, 光滑面

Abstract:

Objective To evaluate the capability of quantitative light-induced fluorescence(QLF) for monitoring the remineralization of lesions lengthways and distinguishing the effect of different fluorides. Methods Following baseline early caries examination, 305 school students(age from 11 to 14 years old)were qualified from Chengdu area. The schools in which the subjects studied were randomized into three groups: NaF group, MFP group and nonfluoride group. The subjects of three groups brushed the teeth with 1 450 mg/L sodium fluoride dentifrice, 1 450 mg/L sodium monofluorophosphate dentifrice and non -fluoride dentifrice, respectively. QLF images of early lesions on smooth surfaces of the maxillary anterior teeth were taken at baseline, three and six months after the initiation of experiment. These images were analyzed by the trained examiner with the area of lesion(Area), fluorescence loss (△F) and gross fluorescence loss quantity(△Q). Results 296 school students completed the study. After three months, the lesions on smooth surfaces got better in all three groups. The change of Area, △F and lg△Q amongst three groups had no statistical significance(P>0.05). After six months, the lesions on smooth surfaces also got better in all three groups than at baseline. The change of Area, △F and lg△Q of the lesions in NaF group and MFP group exhibited significant decreases than that of no-fluoride dentifrice group(P<0.05). But no significantly difference was found between NaF group and MFP group(P>0.05). Conclusion As a diagnostic method which could quantify the miner content, QLF system has the capability of monitoring the variations of lesions lengthways.

Key words: quantitativelight-inducedfluorescence, fluoridedentifrice, earlycaries, smoothsurface