华西口腔医学杂志

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4—6岁儿童唾液免疫生化指标与龋病的关系

黄昊红1;于浩1;张琳2;刘泓2;牛玉梅2;王迺谦2   

  1. 1.齐齐哈尔医学院第二附属医院 口腔科,黑龙江 齐齐哈尔 161006; 2.哈尔滨医科大学口腔医院 口腔内科,黑龙江 哈尔滨 151000
  • 收稿日期:2006-02-25 修回日期:2006-02-25 出版日期:2006-02-20 发布日期:2006-02-20
  • 通讯作者: 黄昊红,Tel:13836241010
  • 作者简介:黄昊红(1968-),女,黑龙江人,副主任医师,硕士
  • 基金资助:

    黑龙江省自然科学基金资助项目(D01-53)

Correlation between Immunochemical Level and Patient With Caries

HUANG Hao-hong1,YU Hao1, ZHANG Lin2, LIU  Hong2,  NIU  Yu-mei2,  WANG  Nai-qian2   

  1. 1. Dept. of Dentistry, The Second Affiliated Hospital of Qiqiha′er Medical College, Qiqiha′er 161006, China; 2. Dept. of  Oral Medicine, College of Stomatology,Haerbin  Medical University,Ha′erbin 151000, China
  • Received:2006-02-25 Revised:2006-02-25 Online:2006-02-20 Published:2006-02-20

摘要:

目的  探讨龋病患者唾液有关免疫生化指标与龋病的关系。方法  收集4—6岁龋病患者、无龋者各45人,共90人,采用免疫放射法测定唾液中分泌型免疫球蛋白A(SIgA)的含量;用比浊法测定其溶菌酶(LZ)含量;用比色法测定其碱性磷酸酶(ALP)、乳酸脱氢酶(LDH)的含量。测定结果用 t 检验进行分析。结果  无龋人群、有龋人群LZ、ALP、SIgA含量的均数之间有显著性差异(P<0.05),无龋人群、有龋人群LDH之间无显著性差异(P>0.05)。
结论  龋病的发生可能与唾液的生化指标有关。

关键词: 龋病, 唾液, 免疫球蛋白,

Abstract:

Objective To explore the relationship between immunochemical level of salivary and caries in children aged 4—6 years old. Methods Two groups were assorted as patients with caries and without caries. Every group included 45 people. Measurements of salivary secretory immunoglobulin A(SIgA)were performed by using radio-immunoassay and single agar diffusion assay. The levels of lysozyme(LZ), alkaline phosphatase(ALP)and lactic dehydrogenase(LDH)were studied with colorimetry and turbidimentry. Results The levels of LDH, SigA, ALP, LZ had significant difference between the two groups(P<0.05). The level of LDH between patients and peoples without caries had little difference(P>0.05). Conclusion The incidence of caries is associated with age, and it may have association with immunochemical levels of salivary.

Key words: caries, salivary, immunoglobulin, enzyme