种植体周围龈沟液中白细胞介素-8含量的测定

华西口腔医学杂志

种植体周围龈沟液中白细胞介素-8含量的测定

邹德荣,朱　红,瞿晓辉

海交通大学附属第六人民医院　口腔科,上海200233

收稿日期:2005-08-25 修回日期:2005-08-25 出版日期:2005-08-20 发布日期:2005-08-20
通讯作者: 邹德荣, Tel: 021-64369181-8581
作者简介:邹德荣(1962-),男,江苏人,教授,硕士

Detection and Measurement of Interleukin-8 in Peri-implant Crevicular Fluid

ZOUDe-rong, ZHUHong, QUXiao-hui.

Dept. ofStomatology, Shanghai Jiao Tong UniversityAffiliated Shanghai Sixth People′sHospital, Shanghai200233, China

Received:2005-08-25 Revised:2005-08-25 Online:2005-08-20 Published:2005-08-20

摘要/Abstract

摘要： 目的　测定种植体周围炎患者龈沟液(GCF)中白细胞介素-8(IL-8)水平,探讨IL-8与种植体周围炎的关系。方法　选择健康种植体和种植体周围炎患者各35例,测定种植体周GCF量并运用双抗体夹心酶联免疫吸附法检测GCF中IL-8总量及浓度;同时检测种植体周临床指标,包括菌斑指数、探诊深度、牙龈指数和松动度。结果　种植体周围炎GCF量、IL-8总量和浓度均高于健康种植体(P<0·01);GCF量、IL-8总量与临床指标之间有正相关关系(P<0·01)。结论　种植体周围GCF量及GCF中IL-8水平的变化与种植体周围炎的发生有关,临床检测GCF 中IL-8水平可作为诊断种植体周围炎的客观指标之一。

关键词: 种植体周围炎, 白细胞介素-8, 临床指标

Abstract: Objective　Gingival crevicular fluid (GCF) analysis of various inflammatory mediators has been investigated as a means of providing objective criteria of peri-implanttissue health. In this report, the crevicularfluid levels of interleukin-8(IL-8), GCF volume and clinical parameters were studied.Methods　GCFwas sampled from 35 healthy and 35 inflamed sites of implan- tation patients. IL-8 levelswere analysed using ABC-ELISA. Clinical parameterswere measured, and data analysiswas performed using the software package SPSS10.0.Results　Significant difference was observed between healthy implant sites and peri-im- plantitis sites. GCF volumewas positively correlatedwith PD, PI, GI andMOB. The total amount of IL-8 was positively correlated with PD and GI.Conclusion　This investigation suggested thatGCF volume and IL-8 cytokine may be of value as a diagnostic and prognostic marker for peri-implantitis.

Key words: peri-implantitis, interleukin-8, clinical parameter

邹德荣,朱红,瞿晓辉. 种植体周围龈沟液中白细胞介素-8含量的测定[J]. 华西口腔医学杂志.

ZOUDe-rong, ZHUHong, QUXiao-hui.. Detection and Measurement of Interleukin-8 in Peri-implant Crevicular Fluid[J]. West China Journal of Stomatology.

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