关键词: 多形性腺瘤, 多形上皮粘蛋白1, E-钙粘蛋白

Abstract:

Objective　To study the relationship of expression of mucin 1 and E-cadherin with recurrence of pleomorphic ade- noma in salivary gland, and to investigate the signal to predictthe recurrence potential of the tumor.Methods　The capsule of tu- mor was observed bymicroscope. The expression ofmucin 1 and E-cadherin in 33 cases of primary adenoma, 12 cases of recurrent pleomorphic adenomas and 7 cases of malignant pleomorphic adenomas were detected by immunohistochemistry.Results　There was no significant difference about the status of capsule and the positive rate of mucin 1 expression between primary and recurrent pleomorphic adenoma (P>0·05). The abnormal distribution of mucin 1 expressionwas observed in recurrent pleomorphic adeno- ma (6/8), whichwas characterized by the positive staining of the whole cytomembrane. On the other hand,positive staining of the primary pleomorphic adenomawas observed on the top of the membrane (19/21). The differencewas statistically significant (P< 0·05). The staining pattern in malignant pleomorphic adenoma was similar with the recurrent ones except higher ratio of positive expression .No significant differentwas observed among the three kind of tumors on the expression rate of E-cadherin(P>0·05). Conclusion　The status of capsule didn′t have much actual usage in predicting the recurrence of pleomorphic adenoma. There was no significant relationship between the expression of E-cd and the recurrence of the tumor. The abnormal distribution of mucin 1 expression contributes to the invasiveness of the tumor and can be used as the predictive signal for recurrence of pleomorphic adenoma.

Key words: plemorphic adenoma, pleomorphic epithelial mucin 1, E-cadherin