关键词: 平阳霉素, 白蛋白微球, 缓释

Abstract:

Objective　The aim of this study was to prepare Pingyangmycin Albumin Microspheres (PYM-AMS) for arterio- venous malformations treatment.Methods　PYM-AMS was prepared at 140℃by the method of emulsification-heat solidification and its characteristicswere evaluated, such as morphosis, particle size, drug loading (DL%), encapsulation efficiency (EE%), stability and drug sustained-releasingin vitro. After being packaged, PYM-AMS were sterilized with 13.7 kGy of60Co. Small samples of PYM-AMS were packaged in small bottles and stored at 3~5℃、15~25℃、37℃for 3 months, then checked the change of morphology、DL、EE and the release rate.Results　The surface of particleswas smooth and integrated. The average di- ameter of PYM-AMS particles was 139.422μm and 80% was in the range of 56~251μm. The mean DL% and EE% were 26·47% and 84.3%, respectively. PYM released fast in 5 h, but then released slowly. 88.65% drugs were released in 24 h, and t50was 1.5 h. There was no obvious change of the morphology、DL、EE and the release rate of PYM-AMS stored at 3~5℃、 15~25℃、37℃for 3 months.Conclusion　PYM-AMS prepared in this study had sustained-release effect, high drug loading and high stability. Albumin is a good carrier of PYM embolization agent.

Key words: pingyangmycin, albumin microspheres, sustained-releasing